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Adult generation of glutamatergic olfactory bulb interneurons

The adult mouse subependymal zone (SEZ) harbours neural stem cells that are thought to generate exclusively GABAergic interneurons of the olfactory bulb. Here we describe the adult generation of glutamatergic juxtaglomerular neurons, with dendritic arborizations that project into adjacent glomeruli...

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Detalles Bibliográficos
Autores principales: Brill, Monika S., Ninkovic, Jovica, Winpenny, Eleanor, Hodge, Rebecca D., Ozen, Ilknur, Yang, Roderick, Lepier, Alexandra, Gascón, Sergio, Erdelyi, Ferenc, Szabo, Gabor, Parras, Carlos, Guillemot, Francois, Frotscher, Michael, Berninger, Benedikt, Hevner, Robert F., Raineteau, Olivier, Götz, Magdalena
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787799/
https://www.ncbi.nlm.nih.gov/pubmed/19881504
http://dx.doi.org/10.1038/nn.2416
Descripción
Sumario:The adult mouse subependymal zone (SEZ) harbours neural stem cells that are thought to generate exclusively GABAergic interneurons of the olfactory bulb. Here we describe the adult generation of glutamatergic juxtaglomerular neurons, with dendritic arborizations that project into adjacent glomeruli identifying them as short-axon cells. Fate mapping revealed that these originate from Neurogenin2- and Tbr2-expressing progenitors located in the dorsal region of the SEZ. Progenitors of these glutamatergic interneurons recapitulate the sequential expression of transcription factors that hallmark glutamatergic neurogenesis in the developing cerebral cortex and adult hippocampus. Indeed, the molecular specification of these SEZ progenitors allows for their recruitment into the cerebral cortex upon lesion. Taken together, our data show that SEZ progenitors not only produce a novel population of adult-born glutamatergic juxtaglomerular neurons, but may also provide a new source of progenitors for endogenous repair.