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Distributed Dynamical Computation in Neural Circuits with Propagating Coherent Activity Patterns

Activity in neural circuits is spatiotemporally organized. Its spatial organization consists of multiple, localized coherent patterns, or patchy clusters. These patterns propagate across the circuits over time. This type of collective behavior has ubiquitously been observed, both in spontaneous acti...

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Detalles Bibliográficos
Autores principales: Gong, Pulin, van Leeuwen, Cees
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787923/
https://www.ncbi.nlm.nih.gov/pubmed/20019807
http://dx.doi.org/10.1371/journal.pcbi.1000611
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author Gong, Pulin
van Leeuwen, Cees
author_facet Gong, Pulin
van Leeuwen, Cees
author_sort Gong, Pulin
collection PubMed
description Activity in neural circuits is spatiotemporally organized. Its spatial organization consists of multiple, localized coherent patterns, or patchy clusters. These patterns propagate across the circuits over time. This type of collective behavior has ubiquitously been observed, both in spontaneous activity and evoked responses; its function, however, has remained unclear. We construct a spatially extended, spiking neural circuit that generates emergent spatiotemporal activity patterns, thereby capturing some of the complexities of the patterns observed empirically. We elucidate what kind of fundamental function these patterns can serve by showing how they process information. As self-sustained objects, localized coherent patterns can signal information by propagating across the neural circuit. Computational operations occur when these emergent patterns interact, or collide with each other. The ongoing behaviors of these patterns naturally embody both distributed, parallel computation and cascaded logical operations. Such distributed computations enable the system to work in an inherently flexible and efficient way. Our work leads us to propose that propagating coherent activity patterns are the underlying primitives with which neural circuits carry out distributed dynamical computation.
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spelling pubmed-27879232009-12-18 Distributed Dynamical Computation in Neural Circuits with Propagating Coherent Activity Patterns Gong, Pulin van Leeuwen, Cees PLoS Comput Biol Research Article Activity in neural circuits is spatiotemporally organized. Its spatial organization consists of multiple, localized coherent patterns, or patchy clusters. These patterns propagate across the circuits over time. This type of collective behavior has ubiquitously been observed, both in spontaneous activity and evoked responses; its function, however, has remained unclear. We construct a spatially extended, spiking neural circuit that generates emergent spatiotemporal activity patterns, thereby capturing some of the complexities of the patterns observed empirically. We elucidate what kind of fundamental function these patterns can serve by showing how they process information. As self-sustained objects, localized coherent patterns can signal information by propagating across the neural circuit. Computational operations occur when these emergent patterns interact, or collide with each other. The ongoing behaviors of these patterns naturally embody both distributed, parallel computation and cascaded logical operations. Such distributed computations enable the system to work in an inherently flexible and efficient way. Our work leads us to propose that propagating coherent activity patterns are the underlying primitives with which neural circuits carry out distributed dynamical computation. Public Library of Science 2009-12-18 /pmc/articles/PMC2787923/ /pubmed/20019807 http://dx.doi.org/10.1371/journal.pcbi.1000611 Text en Gong, van Leeuwen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Gong, Pulin
van Leeuwen, Cees
Distributed Dynamical Computation in Neural Circuits with Propagating Coherent Activity Patterns
title Distributed Dynamical Computation in Neural Circuits with Propagating Coherent Activity Patterns
title_full Distributed Dynamical Computation in Neural Circuits with Propagating Coherent Activity Patterns
title_fullStr Distributed Dynamical Computation in Neural Circuits with Propagating Coherent Activity Patterns
title_full_unstemmed Distributed Dynamical Computation in Neural Circuits with Propagating Coherent Activity Patterns
title_short Distributed Dynamical Computation in Neural Circuits with Propagating Coherent Activity Patterns
title_sort distributed dynamical computation in neural circuits with propagating coherent activity patterns
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787923/
https://www.ncbi.nlm.nih.gov/pubmed/20019807
http://dx.doi.org/10.1371/journal.pcbi.1000611
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