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Aging Mice Show a Decreasing Correlation of Gene Expression within Genetic Modules

In this work we present a method for the differential analysis of gene co-expression networks and apply this method to look for large-scale transcriptional changes in aging. We derived synonymous gene co-expression networks from AGEMAP expression data for 16-month-old and 24-month-old mice. We ident...

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Detalles Bibliográficos
Autores principales: Southworth, Lucinda K., Owen, Art B., Kim, Stuart K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788246/
https://www.ncbi.nlm.nih.gov/pubmed/20019809
http://dx.doi.org/10.1371/journal.pgen.1000776