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Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro

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BACKGROUND: The mitotic arrest deficiency protein 2 (MAD2) is a key component of the mitotic spindle assembly checkpoint, monitoring accurate chromosomal alignment at the metaphase plate before mitosis. MAD2 also has a function in cellular senescence and in a cell's response to microtubule inhi...

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Detalles Bibliográficos
Autores principales:	Prencipe, M, Fitzpatrick, P, Gorman, S, Mosetto, M, Klinger, R, Furlong, F, Harrison, M, O'Connor, D, Roninson, I B, O'Sullivan, J, McCann, A
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788249/ https://www.ncbi.nlm.nih.gov/pubmed/19935801 http://dx.doi.org/10.1038/sj.bjc.6605419

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