Cargando…

A phase I study of the nitroimidazole hypoxia marker SR4554 using (19)F magnetic resonance spectroscopy

BACKGROUND: SR4554 is a fluorine-containing 2-nitroimidazole, designed as a hypoxia marker detectable with (19)F magnetic resonance spectroscopy (MRS). In an initial phase I study of SR4554, nausea/vomiting was found to be dose-limiting, and 1400 mg m(−2) was established as MTD. Preliminary MRS stud...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, C P, Payne, G S, Oregioni, A, Ruddle, R, Tan, S, Raynaud, F I, Eaton, D, Campbell, M J, Cross, K, Halbert, G, Tracy, M, McNamara, J, Seddon, B, Leach, M O, Workman, P, Judson, I
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788261/ https://www.ncbi.nlm.nih.gov/pubmed/19935799 http://dx.doi.org/10.1038/sj.bjc.6605425

Ejemplares similares

The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554.
por: Aboagye, E. O., et al.
Publicado: (1998)

The novel fluorinated 2-nitroimidazole hypoxia probe SR-4554: reductive metabolism and semiquantitative localisation in human ovarian cancer multicellular spheroids as measured by electron energy loss spectroscopic analysis.
por: Aboagye, E. O., et al.
Publicado: (1995)

Chemosensitization by lipophilic nitroimidazoles.
por: Twentyman, P. R., et al.
Publicado: (1983)

Development of a hydroxyflavone-labelled 4554W peptide probe for monitoring αS aggregation
por: Watt, Kathryn J. C., et al.
Publicado: (2023)

The effects of whole body hyperthermia on the pharmacokinetics and toxicity of the basic 2-nitroimidazole radiosensitizer Ro 03-8799 in mice.
por: Walton, M. I., et al.
Publicado: (1987)

In vivo assessment of basic 2-nitroimidazole radiosensitizers.
por: Williams, M. V., et al.
Publicado: (1982)

4554 Researchers’ Experiences Working With Community Advisory Boards: How Community Member and Patient Stakeholder Feedback Impacted The Research
por: Brockman, Tabetha A., et al.
Publicado: (2020)

Design, Synthesis and Anticancer Evaluation of Nitroimidazole Radiosensitisers
por: Liew, Lydia P., et al.
Publicado: (2023)

Nitroimidazole adducts as markers for tissue hypoxia: mechanistic studies in aerobic normal tissues and tumour cells.
por: Parliament, M. B., et al.
Publicado: (1992)

The Role of Nitroreductases in Resistance to Nitroimidazoles
por: Thomas, Carol, et al.
Publicado: (2021)

Core Shell Investigation of 2-nitroimidazole
por: Bolognesi, Paola, et al.
Publicado: (2019)

Imaging latent tuberculosis infection with radiolabeled nitroimidazoles
por: Ankrah, Alfred O., et al.
Publicado: (2016)

In Vitro Susceptibility and Resistance of Mycoplasma genitalium to Nitroimidazoles
por: Wood, Gwendolyn E., et al.
Publicado: (2023)

Infection Control Measures and Prevalence of SARS-CoV-2 IgG among 4,554 University Hospital Employees, Munich, Germany
por: Erber, Johanna, et al.
Publicado: (2022)

Proceedings of the Workshop on the Enhancement of Chemotherapy by Nitroimidazoles
Publicado: (1982)

Treatment of Giardiasis after Nonresponse to Nitroimidazole
por: Meltzer, Eyal, et al.
Publicado: (2014)

Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis
por: Ydsten, Karin A, et al.
Publicado: (2021)

1408. Epidemiology of Nitroimidazole-refractory Giardiasis
por: Ydsten, Karin, et al.
Publicado: (2023)

Interaction of nitroimidazole drugs with DNA in vitro: structure-activity relationships.
por: Knox, R. J., et al.
Publicado: (1981)

Potentiation of melphalan activity against a murine tumour by nitroimidazole compounds.
por: Sheldon, P. W., et al.
Publicado: (1982)

Analysis of the intra- and intertumoral heterogeneity of hypoxia in pancreatic cancer patients receiving the nitroimidazole tracer pimonidazole
por: Dhani, N C, et al.
Publicado: (2015)

Sensitization of normal and malignant tissue to cyclophosphamide by nitroimidazoles with different partition coefficients.
por: Hirst, D. G., et al.
Publicado: (1984)

Efficient preparation of 2-nitroimidazole nucleosides as precursors for hypoxia PET tracers
por: Križková, Petra, et al.
Publicado: (2016)

Cellular mechanism of action of 2-nitroimidazoles as hypoxia-selective therapeutic agents
por: Rashed, Faisal Bin, et al.
Publicado: (2022)

DNA-targeted 2-nitroimidazoles: in vitro and in vivo studies.
por: Cowan, D. S., et al.
Publicado: (1994)

(68)Ga‐nitroimidazole PET/CT imaging of hypoxia in tuberculosis: A case series
por: Bresser, Philippa L, et al.
Publicado: (2022)

Hormonal impact of the 17α-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer
por: O'Donnell, A, et al.
Publicado: (2004)

Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering
por: Lee, Brendon M., et al.
Publicado: (2020)

Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia
por: Umehara, Yui, et al.
Publicado: (2019)

Apoptosis and 1-methyl-2-nitroimidazole toxicity in CHO cells.
por: Brezden, C. B., et al.
Publicado: (1997)

Radiation Damage Mechanisms of Chemotherapeutically Active Nitroimidazole Derived Compounds
por: Chiarinelli, Jacopo, et al.
Publicado: (2019)

A Phase I study of the angiogenesis inhibitor SU5416 (semaxanib) in solid tumours, incorporating dynamic contrast MR pharmacodynamic end points
por: O'Donnell, A, et al.
Publicado: (2005)

Second U.K. workshop on the enhancement of chemotherapy by nitroimidazoles
Publicado: (1983)

Synthesis and Biological Activity of Peptide Derivatives of Iodoquinazolinones/Nitroimidazoles
por: Dahiya, Rajiv, et al.
Publicado: (2008)

Synthesis of New Active Sulfones in the 5-Nitroimidazole Series
por: Benakli, Kamel, et al.
Publicado: (2002)

Electron Ionization of Imidazole and Its Derivative 2-Nitroimidazole
por: Meißner, Rebecca, et al.
Publicado: (2019)

Identification of Trichomonas vaginalis 5-Nitroimidazole Resistance Targets
por: Graves, Keonte J., et al.
Publicado: (2023)

Enhancement of hyperthermochemotherapy for human gastric cancer in nude mice by thermosensitization with nitroimidazoles.
por: Fujimoto, S., et al.
Publicado: (1988)

Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria
por: Zhuang, Zhijun, et al.
Publicado: (2020)

Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid
por: Thompson, Andrew M., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ra0p1mgqv3ras4ijmg414hhu11