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Partial loss of heterozygosity events at the mutated gene in tumors from MLH1/MSH2 large genomic rearrangement carriers

BACKGROUND: Depending on the population studied, large genomic rearrangements (LGRs) of the mismatch repair (MMR) genes constitute various proportions of the germline mutations that predispose to hereditary non-polyposis colorectal cancer (HNPCC). It has been reported that loss of heterozygosity (LO...

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Detalles Bibliográficos
Autores principales:	Zavodna, Katarina, Krivulcik, Tomas, Bujalkova, Maria Gerykova, Slamka, Tomas, Martinicky, David, Ilencikova, Denisa, Bartosova, Zdena
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788582/ https://www.ncbi.nlm.nih.gov/pubmed/19930554 http://dx.doi.org/10.1186/1471-2407-9-405

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