P68 RNA Helicase Is A Nucleocytoplasm Shuttling Protein

P68 RNA helicase is a prototypical DEAD box RNA helicase. The protein plays a very important role in early organ development and maturation. In consistence with the function of the protein in transcriptional regulation and pre-mRNA splicing, p68 was found to predominately localize in the cell nucleu...

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Autores principales: Wang, Haizhen, Gao, Xueliang, Huang, Yun, Yang, Jenny, Liu, Zhi-Ren
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788662/
https://www.ncbi.nlm.nih.gov/pubmed/19786986
http://dx.doi.org/10.1038/cr.2009.113
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author Wang, Haizhen
Gao, Xueliang
Huang, Yun
Yang, Jenny
Liu, Zhi-Ren
author_facet Wang, Haizhen
Gao, Xueliang
Huang, Yun
Yang, Jenny
Liu, Zhi-Ren
author_sort Wang, Haizhen
collection PubMed
description P68 RNA helicase is a prototypical DEAD box RNA helicase. The protein plays a very important role in early organ development and maturation. In consistence with the function of the protein in transcriptional regulation and pre-mRNA splicing, p68 was found to predominately localize in the cell nucleus. However, recent experiments demonstrate a transient cytoplasmic localization of the protein. We report here that p68 shuttles between the nucleus and the cytoplasm. The nucleocytoplasmic shuttling of p68 is mediated by two nuclear localization signal (NLS) and two nuclear exporting signal (NES) sequence elements. Our experiments reveal that p68 shuttles via a classical RanGTPase dependent pathway.
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spelling pubmed-27886622010-06-01 P68 RNA Helicase Is A Nucleocytoplasm Shuttling Protein Wang, Haizhen Gao, Xueliang Huang, Yun Yang, Jenny Liu, Zhi-Ren Cell Res Article P68 RNA helicase is a prototypical DEAD box RNA helicase. The protein plays a very important role in early organ development and maturation. In consistence with the function of the protein in transcriptional regulation and pre-mRNA splicing, p68 was found to predominately localize in the cell nucleus. However, recent experiments demonstrate a transient cytoplasmic localization of the protein. We report here that p68 shuttles between the nucleus and the cytoplasm. The nucleocytoplasmic shuttling of p68 is mediated by two nuclear localization signal (NLS) and two nuclear exporting signal (NES) sequence elements. Our experiments reveal that p68 shuttles via a classical RanGTPase dependent pathway. 2009-09-29 2009-12 /pmc/articles/PMC2788662/ /pubmed/19786986 http://dx.doi.org/10.1038/cr.2009.113 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Wang, Haizhen
Gao, Xueliang
Huang, Yun
Yang, Jenny
Liu, Zhi-Ren
P68 RNA Helicase Is A Nucleocytoplasm Shuttling Protein
title P68 RNA Helicase Is A Nucleocytoplasm Shuttling Protein
title_full P68 RNA Helicase Is A Nucleocytoplasm Shuttling Protein
title_fullStr P68 RNA Helicase Is A Nucleocytoplasm Shuttling Protein
title_full_unstemmed P68 RNA Helicase Is A Nucleocytoplasm Shuttling Protein
title_short P68 RNA Helicase Is A Nucleocytoplasm Shuttling Protein
title_sort p68 rna helicase is a nucleocytoplasm shuttling protein
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788662/
https://www.ncbi.nlm.nih.gov/pubmed/19786986
http://dx.doi.org/10.1038/cr.2009.113
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AT yangjenny p68rnahelicaseisanucleocytoplasmshuttlingprotein
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