T Cell Detection of a B-Cell Tropic Virus Infection: Newly-Synthesised versus Mature Viral Proteins as Antigen Sources for CD4 and CD8 Epitope Display

Viruses that naturally infect cells expressing both MHC I and MHC II molecules render themselves potentially visible to both CD8(+) and CD4(+) T cells through the de novo expression of viral antigens. Here we use one such pathogen, the B-lymphotropic Epstein-Barr virus (EBV), to examine the kinetics...

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Detalles Bibliográficos
Autores principales: Mackay, Laura K., Long, Heather M., Brooks, Jill M., Taylor, Graham S., Leung, Carol S., Chen, Adrienne, Wang, Fred, Rickinson, Alan B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788701/
https://www.ncbi.nlm.nih.gov/pubmed/20019813
http://dx.doi.org/10.1371/journal.ppat.1000699

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