Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors

A series of imidazopyrimidine derivatives with the general formula I was synthesized and identified as potent inhibitors of iNOS dimer formation, a prerequisite for proper functioning of the enzyme. Stille and Negishi coupling reactions were used as key steps to form the carbon-carbon bond connectin...

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Autores principales: Chu, Guo-Hua, Le Bourdonnec, Bertrand, Gu, Minghua, Ajello, Christopher W, Leister, Lara K, Sellitto, Ian, Cassel, Joel A, Tuthill, Paul A, O’ Hare, Heather, DeHaven, Robert N, Dolle, Roland E
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788740/
https://www.ncbi.nlm.nih.gov/pubmed/19966921
http://dx.doi.org/10.2174/1874104500903010008
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author Chu, Guo-Hua
Le Bourdonnec, Bertrand
Gu, Minghua
Ajello, Christopher W
Leister, Lara K
Sellitto, Ian
Cassel, Joel A
Tuthill, Paul A
O’ Hare, Heather
DeHaven, Robert N
Dolle, Roland E
author_facet Chu, Guo-Hua
Le Bourdonnec, Bertrand
Gu, Minghua
Ajello, Christopher W
Leister, Lara K
Sellitto, Ian
Cassel, Joel A
Tuthill, Paul A
O’ Hare, Heather
DeHaven, Robert N
Dolle, Roland E
author_sort Chu, Guo-Hua
collection PubMed
description A series of imidazopyrimidine derivatives with the general formula I was synthesized and identified as potent inhibitors of iNOS dimer formation, a prerequisite for proper functioning of the enzyme. Stille and Negishi coupling reactions were used as key steps to form the carbon-carbon bond connecting the imidazopyrimidine core to the central cycloalkenyl, cycloalkyl and phenyl ring templates.
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spelling pubmed-27887402009-12-04 Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors Chu, Guo-Hua Le Bourdonnec, Bertrand Gu, Minghua Ajello, Christopher W Leister, Lara K Sellitto, Ian Cassel, Joel A Tuthill, Paul A O’ Hare, Heather DeHaven, Robert N Dolle, Roland E Open Med Chem J Article A series of imidazopyrimidine derivatives with the general formula I was synthesized and identified as potent inhibitors of iNOS dimer formation, a prerequisite for proper functioning of the enzyme. Stille and Negishi coupling reactions were used as key steps to form the carbon-carbon bond connecting the imidazopyrimidine core to the central cycloalkenyl, cycloalkyl and phenyl ring templates. Bentham Open 2009-11-18 /pmc/articles/PMC2788740/ /pubmed/19966921 http://dx.doi.org/10.2174/1874104500903010008 Text en © Chu et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/)which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Chu, Guo-Hua
Le Bourdonnec, Bertrand
Gu, Minghua
Ajello, Christopher W
Leister, Lara K
Sellitto, Ian
Cassel, Joel A
Tuthill, Paul A
O’ Hare, Heather
DeHaven, Robert N
Dolle, Roland E
Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors
title Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors
title_full Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors
title_fullStr Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors
title_full_unstemmed Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors
title_short Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors
title_sort design and synthesis of imidazopyrimidine derivatives as potent inos dimerization inhibitors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788740/
https://www.ncbi.nlm.nih.gov/pubmed/19966921
http://dx.doi.org/10.2174/1874104500903010008
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