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Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors
A series of imidazopyrimidine derivatives with the general formula I was synthesized and identified as potent inhibitors of iNOS dimer formation, a prerequisite for proper functioning of the enzyme. Stille and Negishi coupling reactions were used as key steps to form the carbon-carbon bond connectin...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Bentham Open
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788740/ https://www.ncbi.nlm.nih.gov/pubmed/19966921 http://dx.doi.org/10.2174/1874104500903010008 |