Cargando…

The TGF-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients

BACKGROUD: The underlying molecular and cellular mechanisms of radiation pneumonitis (RP) are very complex. Several biological factors need to be considered together with the well known dosimetric parameters for understanding the molecular events in developing RP in lung cancer patients. The aim of...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Ji-Yoon, Kim, Yeon-Sil, Kim, Young-Kyoon, Park, Hyun-Jin, Kim, Seung-Joon, Kang, Jin-Hyoung, Wang, Young-Pil, Jang, Hong-Seok, Lee, Sang-Nam, Yoon, Sei-Chul
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789091/
https://www.ncbi.nlm.nih.gov/pubmed/19943923
http://dx.doi.org/10.1186/1748-717X-4-59
_version_ 1782175031355244544
author Kim, Ji-Yoon
Kim, Yeon-Sil
Kim, Young-Kyoon
Park, Hyun-Jin
Kim, Seung-Joon
Kang, Jin-Hyoung
Wang, Young-Pil
Jang, Hong-Seok
Lee, Sang-Nam
Yoon, Sei-Chul
author_facet Kim, Ji-Yoon
Kim, Yeon-Sil
Kim, Young-Kyoon
Park, Hyun-Jin
Kim, Seung-Joon
Kang, Jin-Hyoung
Wang, Young-Pil
Jang, Hong-Seok
Lee, Sang-Nam
Yoon, Sei-Chul
author_sort Kim, Ji-Yoon
collection PubMed
description BACKGROUD: The underlying molecular and cellular mechanisms of radiation pneumonitis (RP) are very complex. Several biological factors need to be considered together with the well known dosimetric parameters for understanding the molecular events in developing RP in lung cancer patients. The aim of this study was to correlate the variations of the cytokine levels in lung cancer patients during radiation therapy (RT) with the occurrence of symptomatic RP. METHODS: Thirty-four lung cancer patients who received three-dimensional conformal radiation therapy were evaluated prospectively. Serial blood samples before, at the beginning, in the middle of, at the end of RT and 2 and 4 weeks after RT were analyzed for IL-1α, IL-6, IL-10, TNF-α and TGF-β1 by performing enzyme-linked immunosorbent assay. The predictive values of dosimetric factors for RP were evaluated, too. RESULTS: Overall, 8 patients (23.5%) had grade ≥ 2 RP. By serial measurement of cytokines level, only the TGF-β1 level showed a correlation to the symptomatic RP. None of the other cytokines, IL-1α, IL-6, IL-10 and TNF-α level was correlated with the risk of RP. The mean pretreatment TGF-β1 level did not differ between RP and non-RP groups. However, during the period of radiation treatment, the TGF-β1 level began to increase at the end of RT in the RP group and became significantly higher 4 weeks after RT (p = 0.007). Using an ANOVA model for repeated-measures, we found significant associations between the changes of TGF-β1 during the time course of the RT and the risk of developing RP (p < 0.001). Most of the dosimetric factors showed a significant association with RP. CONCLUSION: Our results show that the changes of TGF-β1 could be correlated with RP and the incorporation of the biological parameters into the dosimetric data could be useful for predicting symptomatic RP.
format Text
id pubmed-2789091
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-27890912009-12-05 The TGF-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients Kim, Ji-Yoon Kim, Yeon-Sil Kim, Young-Kyoon Park, Hyun-Jin Kim, Seung-Joon Kang, Jin-Hyoung Wang, Young-Pil Jang, Hong-Seok Lee, Sang-Nam Yoon, Sei-Chul Radiat Oncol Research BACKGROUD: The underlying molecular and cellular mechanisms of radiation pneumonitis (RP) are very complex. Several biological factors need to be considered together with the well known dosimetric parameters for understanding the molecular events in developing RP in lung cancer patients. The aim of this study was to correlate the variations of the cytokine levels in lung cancer patients during radiation therapy (RT) with the occurrence of symptomatic RP. METHODS: Thirty-four lung cancer patients who received three-dimensional conformal radiation therapy were evaluated prospectively. Serial blood samples before, at the beginning, in the middle of, at the end of RT and 2 and 4 weeks after RT were analyzed for IL-1α, IL-6, IL-10, TNF-α and TGF-β1 by performing enzyme-linked immunosorbent assay. The predictive values of dosimetric factors for RP were evaluated, too. RESULTS: Overall, 8 patients (23.5%) had grade ≥ 2 RP. By serial measurement of cytokines level, only the TGF-β1 level showed a correlation to the symptomatic RP. None of the other cytokines, IL-1α, IL-6, IL-10 and TNF-α level was correlated with the risk of RP. The mean pretreatment TGF-β1 level did not differ between RP and non-RP groups. However, during the period of radiation treatment, the TGF-β1 level began to increase at the end of RT in the RP group and became significantly higher 4 weeks after RT (p = 0.007). Using an ANOVA model for repeated-measures, we found significant associations between the changes of TGF-β1 during the time course of the RT and the risk of developing RP (p < 0.001). Most of the dosimetric factors showed a significant association with RP. CONCLUSION: Our results show that the changes of TGF-β1 could be correlated with RP and the incorporation of the biological parameters into the dosimetric data could be useful for predicting symptomatic RP. BioMed Central 2009-11-27 /pmc/articles/PMC2789091/ /pubmed/19943923 http://dx.doi.org/10.1186/1748-717X-4-59 Text en Copyright ©2009 Kim et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Kim, Ji-Yoon
Kim, Yeon-Sil
Kim, Young-Kyoon
Park, Hyun-Jin
Kim, Seung-Joon
Kang, Jin-Hyoung
Wang, Young-Pil
Jang, Hong-Seok
Lee, Sang-Nam
Yoon, Sei-Chul
The TGF-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients
title The TGF-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients
title_full The TGF-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients
title_fullStr The TGF-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients
title_full_unstemmed The TGF-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients
title_short The TGF-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients
title_sort tgf-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789091/
https://www.ncbi.nlm.nih.gov/pubmed/19943923
http://dx.doi.org/10.1186/1748-717X-4-59
work_keys_str_mv AT kimjiyoon thetgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT kimyeonsil thetgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT kimyoungkyoon thetgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT parkhyunjin thetgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT kimseungjoon thetgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT kangjinhyoung thetgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT wangyoungpil thetgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT janghongseok thetgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT leesangnam thetgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT yoonseichul thetgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT kimjiyoon tgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT kimyeonsil tgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT kimyoungkyoon tgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT parkhyunjin tgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT kimseungjoon tgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT kangjinhyoung tgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT wangyoungpil tgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT janghongseok tgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT leesangnam tgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients
AT yoonseichul tgfb1dynamicsduringradiationtherapyanditscorrelationtosymptomaticradiationpneumonitisinlungcancerpatients