A regulatory domain spanning the repeat sequence RE1 from herpes simplex virus type 1 has cell specific differential functions in trigeminal neurons and fibroblasts

In this report we demonstrate that the herpes simplex virus type 1 reiteration element 1 (RE1) (nt: 117158–117353) in concert with its flanking sequences is both a cell specific and stimulus inducible regulatory domain. This region of the virus genome and specifically the RE1 supports differential r...

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Autores principales: Stevens, Hannah C., Fiskerstrand, Carolyn, Bubb, Vivien J., Dalziel, Robert, Quinn, John P.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789235/
https://www.ncbi.nlm.nih.gov/pubmed/19786025
http://dx.doi.org/10.1016/j.febslet.2009.09.037
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author Stevens, Hannah C.
Fiskerstrand, Carolyn
Bubb, Vivien J.
Dalziel, Robert
Quinn, John P.
author_facet Stevens, Hannah C.
Fiskerstrand, Carolyn
Bubb, Vivien J.
Dalziel, Robert
Quinn, John P.
author_sort Stevens, Hannah C.
collection PubMed
description In this report we demonstrate that the herpes simplex virus type 1 reiteration element 1 (RE1) (nt: 117158–117353) in concert with its flanking sequences is both a cell specific and stimulus inducible regulatory domain. This region of the virus genome and specifically the RE1 supports differential reporter gene expression in both baby hamster kidney cells and disassociated rat trigeminal ganglia and is present within a region that is implicated in regulating latency of the virus in neuronal cells. Further we demonstrate that this locus is a transcriptional regulatory domain and a target for the transcription factor CCCTC binding protein.
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spelling pubmed-27892352009-12-22 A regulatory domain spanning the repeat sequence RE1 from herpes simplex virus type 1 has cell specific differential functions in trigeminal neurons and fibroblasts Stevens, Hannah C. Fiskerstrand, Carolyn Bubb, Vivien J. Dalziel, Robert Quinn, John P. FEBS Lett Article In this report we demonstrate that the herpes simplex virus type 1 reiteration element 1 (RE1) (nt: 117158–117353) in concert with its flanking sequences is both a cell specific and stimulus inducible regulatory domain. This region of the virus genome and specifically the RE1 supports differential reporter gene expression in both baby hamster kidney cells and disassociated rat trigeminal ganglia and is present within a region that is implicated in regulating latency of the virus in neuronal cells. Further we demonstrate that this locus is a transcriptional regulatory domain and a target for the transcription factor CCCTC binding protein. Elsevier Science B.V 2009-10-20 /pmc/articles/PMC2789235/ /pubmed/19786025 http://dx.doi.org/10.1016/j.febslet.2009.09.037 Text en © 2009 Elsevier B.V. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Stevens, Hannah C.
Fiskerstrand, Carolyn
Bubb, Vivien J.
Dalziel, Robert
Quinn, John P.
A regulatory domain spanning the repeat sequence RE1 from herpes simplex virus type 1 has cell specific differential functions in trigeminal neurons and fibroblasts
title A regulatory domain spanning the repeat sequence RE1 from herpes simplex virus type 1 has cell specific differential functions in trigeminal neurons and fibroblasts
title_full A regulatory domain spanning the repeat sequence RE1 from herpes simplex virus type 1 has cell specific differential functions in trigeminal neurons and fibroblasts
title_fullStr A regulatory domain spanning the repeat sequence RE1 from herpes simplex virus type 1 has cell specific differential functions in trigeminal neurons and fibroblasts
title_full_unstemmed A regulatory domain spanning the repeat sequence RE1 from herpes simplex virus type 1 has cell specific differential functions in trigeminal neurons and fibroblasts
title_short A regulatory domain spanning the repeat sequence RE1 from herpes simplex virus type 1 has cell specific differential functions in trigeminal neurons and fibroblasts
title_sort regulatory domain spanning the repeat sequence re1 from herpes simplex virus type 1 has cell specific differential functions in trigeminal neurons and fibroblasts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789235/
https://www.ncbi.nlm.nih.gov/pubmed/19786025
http://dx.doi.org/10.1016/j.febslet.2009.09.037
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