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Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi()

As part of a drug discovery programme to discover new treatments for human African trypanosomiasis, recombinant trypanothione reductase from Trypanosoma brucei has been expressed, purified and characterized. The crystal structure was solved by molecular replacement to a resolution of 2.3 Å and found...

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Detalles Bibliográficos
Autores principales:	Jones, Deuan C., Ariza, Antonio, Chow, Wing-Huen A., Oza, Sandra L., Fairlamb, Alan H.
Formato:	Texto
Lenguaje:	English
Publicado:	Elsevier/North-Holland Biomedical Press 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789240/ https://www.ncbi.nlm.nih.gov/pubmed/19747949 http://dx.doi.org/10.1016/j.molbiopara.2009.09.002

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