A retinoic acid receptor β agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord

After spinal cord injury in the adult mammal, axons do not normally regrow and this commonly leads to paralysis. Retinoic acid (RA) can stimulate neurite outgrowth in vitro of both the embryonic central and peripheral nervous system, via activation of the retinoic acid receptor (RAR) β2. We show her...

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Detalles Bibliográficos
Autores principales: Agudo, Marta, Yip, Ping, Davies, Meirion, Bradbury, Elizabeth, Doherty, Patrick, McMahon, Stephen, Maden, Malcolm, Corcoran, Jonathan P.T.
Formato: Texto
Lenguaje:English
Publicado: Academic Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789321/
https://www.ncbi.nlm.nih.gov/pubmed/19800972
http://dx.doi.org/10.1016/j.nbd.2009.09.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789321/
https://www.ncbi.nlm.nih.gov/pubmed/19800972
http://dx.doi.org/10.1016/j.nbd.2009.09.018

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