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Ethacrynic Acid Exhibits Selective Toxicity to Chronic Lymphocytic Leukemia Cells by Inhibition of the Wnt/β-Catenin Pathway

BACKGROUND: Aberrant activation of Wnt/β-catenin signaling promotes the development of several cancers. It has been demonstrated that the Wnt signaling pathway is activated in chronic lymphocytic leukemia (CLL) cells, and that uncontrolled Wnt/β-catenin signaling may contribute to the defect in apop...

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Detalles Bibliográficos
Autores principales:	Lu, Desheng, Liu, Jerry X., Endo, Tomoyuki, Zhou, Haowen, Yao, Shiyin, Willert, Karl, Schmidt-Wolf, Ingo G. H., Kipps, Thomas J., Carson, Dennis A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789382/ https://www.ncbi.nlm.nih.gov/pubmed/20011538 http://dx.doi.org/10.1371/journal.pone.0008294

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