Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent

A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron is...

Descripción completa

Detalles Bibliográficos
Autores principales: Samei, Ehsan, Saunders, Robert S, Badea, Cristian T, Ghaghada, Ketan B, Hedlund, Laurence W, Qi, Yi, Yuan, Hong, Bentley, Rex C, Mukundan, Srinivasan
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2009
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789439/
https://www.ncbi.nlm.nih.gov/pubmed/20011244
_version_ 1782175050640654336
author Samei, Ehsan
Saunders, Robert S
Badea, Cristian T
Ghaghada, Ketan B
Hedlund, Laurence W
Qi, Yi
Yuan, Hong
Bentley, Rex C
Mukundan, Srinivasan
author_facet Samei, Ehsan
Saunders, Robert S
Badea, Cristian T
Ghaghada, Ketan B
Hedlund, Laurence W
Qi, Yi
Yuan, Hong
Bentley, Rex C
Mukundan, Srinivasan
author_sort Samei, Ehsan
collection PubMed
description A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron isotropic resolution. The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies.
format Text
id pubmed-2789439
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-27894392009-12-14 Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent Samei, Ehsan Saunders, Robert S Badea, Cristian T Ghaghada, Ketan B Hedlund, Laurence W Qi, Yi Yuan, Hong Bentley, Rex C Mukundan, Srinivasan Int J Nanomedicine Original Research A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron isotropic resolution. The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies. Dove Medical Press 2009 2009-11-23 /pmc/articles/PMC2789439/ /pubmed/20011244 Text en © 2009 Samei et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Samei, Ehsan
Saunders, Robert S
Badea, Cristian T
Ghaghada, Ketan B
Hedlund, Laurence W
Qi, Yi
Yuan, Hong
Bentley, Rex C
Mukundan, Srinivasan
Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent
title Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent
title_full Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent
title_fullStr Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent
title_full_unstemmed Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent
title_short Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent
title_sort micro-ct imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789439/
https://www.ncbi.nlm.nih.gov/pubmed/20011244
work_keys_str_mv AT sameiehsan microctimagingofbreasttumorsinrodentsusingaliposomalnanoparticlecontrastagent
AT saundersroberts microctimagingofbreasttumorsinrodentsusingaliposomalnanoparticlecontrastagent
AT badeacristiant microctimagingofbreasttumorsinrodentsusingaliposomalnanoparticlecontrastagent
AT ghaghadaketanb microctimagingofbreasttumorsinrodentsusingaliposomalnanoparticlecontrastagent
AT hedlundlaurencew microctimagingofbreasttumorsinrodentsusingaliposomalnanoparticlecontrastagent
AT qiyi microctimagingofbreasttumorsinrodentsusingaliposomalnanoparticlecontrastagent
AT yuanhong microctimagingofbreasttumorsinrodentsusingaliposomalnanoparticlecontrastagent
AT bentleyrexc microctimagingofbreasttumorsinrodentsusingaliposomalnanoparticlecontrastagent
AT mukundansrinivasan microctimagingofbreasttumorsinrodentsusingaliposomalnanoparticlecontrastagent

Ejemplares similares