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GOAT links dietary lipids with the endocrine control of energy balance
CNS nutrient sensing and afferent endocrine signalling are established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find t...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789701/ https://www.ncbi.nlm.nih.gov/pubmed/19503064 http://dx.doi.org/10.1038/nm.1997 |
| _version_ | 1782175061652799488 |
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| author | Kirchner, H. Gutierrez, J.A. Solenberg, P.J. Pfluger, P.T. Czyzyk, T.A. Willency, J.A. Schurmann, A. Joost, H.G. Jandacek, R. Hale, J.E. Heiman, M.L. Tschöp, M.H. |
| author_facet | Kirchner, H. Gutierrez, J.A. Solenberg, P.J. Pfluger, P.T. Czyzyk, T.A. Willency, J.A. Schurmann, A. Joost, H.G. Jandacek, R. Hale, J.E. Heiman, M.L. Tschöp, M.H. |
| author_sort | Kirchner, H. |
| collection | PubMed |
| description | CNS nutrient sensing and afferent endocrine signalling are established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT) which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and modulates body fat mass in mice. |
| format | Text |
| id | pubmed-2789701 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-27897012010-01-01 GOAT links dietary lipids with the endocrine control of energy balance Kirchner, H. Gutierrez, J.A. Solenberg, P.J. Pfluger, P.T. Czyzyk, T.A. Willency, J.A. Schurmann, A. Joost, H.G. Jandacek, R. Hale, J.E. Heiman, M.L. Tschöp, M.H. Nat Med Article CNS nutrient sensing and afferent endocrine signalling are established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT) which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and modulates body fat mass in mice. 2009-06-05 2009-07 /pmc/articles/PMC2789701/ /pubmed/19503064 http://dx.doi.org/10.1038/nm.1997 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Kirchner, H. Gutierrez, J.A. Solenberg, P.J. Pfluger, P.T. Czyzyk, T.A. Willency, J.A. Schurmann, A. Joost, H.G. Jandacek, R. Hale, J.E. Heiman, M.L. Tschöp, M.H. GOAT links dietary lipids with the endocrine control of energy balance |
| title | GOAT links dietary lipids with the endocrine control of energy balance |
| title_full | GOAT links dietary lipids with the endocrine control of energy balance |
| title_fullStr | GOAT links dietary lipids with the endocrine control of energy balance |
| title_full_unstemmed | GOAT links dietary lipids with the endocrine control of energy balance |
| title_short | GOAT links dietary lipids with the endocrine control of energy balance |
| title_sort | goat links dietary lipids with the endocrine control of energy balance |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789701/ https://www.ncbi.nlm.nih.gov/pubmed/19503064 http://dx.doi.org/10.1038/nm.1997 |
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