Prion protein self-peptides modulate prion interactions and conversion

BACKGROUND: Molecular mechanisms underlying prion agent replication, converting host-encoded cellular prion protein (PrP(C)) into the scrapie associated isoform (PrP(Sc)), are poorly understood. Selective self-interaction between PrP molecules forms a basis underlying the observed differences of the...

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Detalles Bibliográficos
Autores principales: Rigter, Alan, Priem, Jan, Timmers-Parohi, Drophatie, Langeveld, Jan PM, van Zijderveld, Fred G, Bossers, Alex
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789745/
https://www.ncbi.nlm.nih.gov/pubmed/19943977
http://dx.doi.org/10.1186/1471-2091-10-29

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