Cargando…

Effects of muscarinic receptor stimulation on Ca(2+) transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells

We investigated the contribution of the intracellular calcium (Ca(i)(2+)) transient to acetylcholine (ACh)-mediated reduction of pacemaker frequency and cAMP content in rabbit sinoatrial nodal (SAN) cells. Action potentials (whole cell perforated patch clamp) and Ca(i)(2+) transients (Indo-1 fluores...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Borren, Marcel M. G. J., Verkerk, Arie O., Wilders, Ronald, Hajji, Najat, Zegers, Jan G., Bourier, Jan, Tan, Hanno L., Verheijck, Etienne E., Peters, Stephan L. M., Alewijnse, Astrid E., Ravesloot, Jan-Hindrik
Formato:	Texto
Lenguaje:	English
Publicado:	D. Steinkopff-Verlag 2009
Materias:	Original Contribution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789936/ https://www.ncbi.nlm.nih.gov/pubmed/19639379 http://dx.doi.org/10.1007/s00395-009-0048-9

Ejemplares similares

Calcium Transient and Sodium-Calcium Exchange Current in Human versus Rabbit Sinoatrial Node Pacemaker Cells
por: Verkerk, Arie O., et al.
Publicado: (2013)

Is sodium current present in human sinoatrial node cells?
por: Verkerk, Arie O., et al.
Publicado: (2009)

Hyperpolarization-Activated Current, I (f), in Mathematical Models of Rabbit Sinoatrial Node Pacemaker Cells
por: Verkerk, Arie O., et al.
Publicado: (2013)

Pacemaker Activity of the Human Sinoatrial Node: An Update on the Effects of Mutations in HCN4 on the Hyperpolarization-Activated Current
por: Verkerk, Arie O., et al.
Publicado: (2015)

Human Sinoatrial Node Pacemaker Activity: Role of the Slow Component of the Delayed Rectifier K(+) Current, I(Ks)
por: Verkerk, Arie O., et al.
Publicado: (2023)

Pacemaker Synchronization of Electrically Coupled Rabbit Sinoatrial Node Cells
por: Verheijck, E. Etienne, et al.
Publicado: (1998)

Ca(2+) cycling properties are conserved despite bradycardic effects of heart failure in sinoatrial node cells
por: Verkerk, Arie O., et al.
Publicado: (2015)

cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells
por: Fenske, Stefanie, et al.
Publicado: (2020)

Effects of Acetylcholine and Noradrenalin on Action Potentials of Isolated Rabbit Sinoatrial and Atrial Myocytes
por: Verkerk, Arie O., et al.
Publicado: (2012)

Cyclic AMP reverses the effects of aging on pacemaker activity and I(f) in sinoatrial node myocytes
por: Sharpe, Emily J., et al.
Publicado: (2017)

Patch-Clamp Recording from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Improving Action Potential Characteristics through Dynamic Clamp
por: Verkerk, Arie O., et al.
Publicado: (2017)

Dietary Omega-3 Polyunsaturated Fatty Acids Suppress NHE-1 Upregulation in a Rabbit Model of Volume- and Pressure-Overload
por: van Borren, Marcel M. G. J., et al.
Publicado: (2012)

Sinoatrial node pacemaker cells: cardiomyocyte- or neuron-like cells?
por: Zhou, Bin
Publicado: (2021)

The end effector of circadian heart rate variation: the sinoatrial node pacemaker cell
por: Yaniv, Yael, et al.
Publicado: (2015)

Ion channelopathies in human induced pluripotent stem cell derived cardiomyocytes: a dynamic clamp study with virtual I(K1)
por: Meijer van Putten, Rosalie M. E., et al.
Publicado: (2015)

Genetic Regulation of Sinoatrial Node Development and Pacemaker Program in the Venous Pole
por: Ye, Wenduo, et al.
Publicado: (2015)

Pregnancy and oestrogen regulate sinoatrial node calcium homeostasis and accelerate pacemaking
por: El Khoury, Nabil, et al.
Publicado: (2018)

Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis
por: Easterling, Marietta, et al.
Publicado: (2021)

Patch-Clamp Recordings of Action Potentials From Human Atrial Myocytes: Optimization Through Dynamic Clamp
por: Verkerk, Arie O., et al.
Publicado: (2021)

Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons
por: Liang, Dandan, et al.
Publicado: (2021)

Drivers of Sinoatrial Node Automaticity in Zebrafish: Comparison With Mechanisms of Mammalian Pacemaker Function
por: Stoyek, Matthew R., et al.
Publicado: (2022)

Long QT Syndrome and Sinus Bradycardia–A Mini Review
por: Wilders, Ronald, et al.
Publicado: (2018)

The Action Potential Clamp Technique as a Tool for Risk Stratification of Sinus Bradycardia Due to Loss-of-Function Mutations in HCN4: An In Silico Exploration Based on In Vitro and In Vivo Data
por: Verkerk, Arie O., et al.
Publicado: (2023)

Role of cAMP in Double Switch of Glucagon Secretion
por: Zmazek, Jan, et al.
Publicado: (2021)

Transcriptome profile of the sinoatrial ring reveals conserved and novel genetic programs of the zebrafish pacemaker
por: Minhas, Rashid, et al.
Publicado: (2021)

Intracellular Na(+) Modulates Pacemaking Activity in Murine Sinoatrial Node Myocytes: An In Silico Analysis
por: Morotti, Stefano, et al.
Publicado: (2021)

Transcriptional and Epigenetic Landscape of Cardiac Pacemaker Cells: Insights Into Cellular Specialization in the Sinoatrial Node
por: Mandla, Ravi, et al.
Publicado: (2021)

Carbamazepine Increases the Risk of Sudden Cardiac Arrest by a Reduction of the Cardiac Sodium Current
por: Jia, Lixia, et al.
Publicado: (2022)

Sphingosine‐1‐Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca(2+) Sensitivity and Na(+)/H(+) Exchange and Mediates Protection by Ischemic Preconditioning
por: Keul, Petra, et al.
Publicado: (2016)

Increase in Ca(2+)-Activated cAMP/PKA Signaling Prevents Hydroxychloroquine-Induced Bradycardia of the Cardiac Pacemaker
por: Segal, Sofia, et al.
Publicado: (2022)

The Antidepressant Paroxetine Reduces the Cardiac Sodium Current
por: Plijter, Ingmar S., et al.
Publicado: (2023)

Complete Atrial-Specific Knockout of Sodium-Calcium Exchange Eliminates Sinoatrial Node Pacemaker Activity
por: Groenke, Sabine, et al.
Publicado: (2013)

HCN4 pacemaker channels attenuate the parasympathetic response and stabilize the spontaneous firing of the sinoatrial node
por: Kozasa, Yuko, et al.
Publicado: (2018)

Functional Heterogeneity of Cell Populations Increases Robustness of Pacemaker Function in a Numerical Model of the Sinoatrial Node Tissue
por: Maltsev, Alexander V., et al.
Publicado: (2022)

Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study
por: Alghamdi, Azzah M., et al.
Publicado: (2020)

Multiple Facets of cAMP Signalling and Physiological Impact: cAMP Compartmentalization in the Lung
por: Oldenburger, Anouk, et al.
Publicado: (2012)

Cyclic Nucleotide-Specific Optogenetics Highlights Compartmentalization of the Sperm Flagellum into cAMP Microdomains
por: Raju, Diana N., et al.
Publicado: (2019)

Aquaporin Channels in the Heart—Physiology and Pathophysiology
por: Verkerk, Arie O., et al.
Publicado: (2019)

cAMP crosses junctions
por: Bashyam, Hema
Publicado: (2007)

Mitochondrial cAMP signaling
por: Zhang, Fan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_pvu9qvvfqammvlt0lqr10rraqr