Direct cell reprogramming is a stochastic process amenable to acceleration

Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) can be achieved by overexpression of Oct4, Sox2, Klf4 and c-Myc transcription factors, but only a minority of donor somatic cells can be reprogrammed to pluripotency. Here we demonstrate that reprogramming is a continu...

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Detalles Bibliográficos
Autores principales: Hanna, Jacob, Saha, Krishanu, Pando, Bernardo, van Zon, Jeroen, Lengner, Christopher J., Creyghton, Menno P., van Oudenaarden, Alexander, Jaenisch, Rudolf
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789972/
https://www.ncbi.nlm.nih.gov/pubmed/19898493
http://dx.doi.org/10.1038/nature08592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789972/
https://www.ncbi.nlm.nih.gov/pubmed/19898493
http://dx.doi.org/10.1038/nature08592

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