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The Potential for Xanthine Oxidase Inhibition in the Prevention and Treatment of Cardiovascular and Cerebrovascular Disease
There is a now a wealth of epidemiological, animal, and clinical data to suggest the benefits of uric acid reduction and hxanthine oxidase inhibition in prevention of vascular disease. This review discusses the available epidemiological, preclinical, and clinical data and considers arguments for and...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790135/ https://www.ncbi.nlm.nih.gov/pubmed/20029618 http://dx.doi.org/10.1155/2009/282059 |
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author | Higgins, Peter Dawson, Jesse Walters, Matthew |
author_facet | Higgins, Peter Dawson, Jesse Walters, Matthew |
author_sort | Higgins, Peter |
collection | PubMed |
description | There is a now a wealth of epidemiological, animal, and clinical data to suggest the benefits of uric acid reduction and hxanthine oxidase inhibition in prevention of vascular disease. This review discusses the available epidemiological, preclinical, and clinical data and considers arguments for and against a role for serum uric acid in common cardiovascular disorders. It concludes that large scale trials with clinical endpoints are justified to address this important question and to define whether use of drugs such as allopurinol should be a routine part of preventative strategies. |
format | Text |
id | pubmed-2790135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-27901352009-12-22 The Potential for Xanthine Oxidase Inhibition in the Prevention and Treatment of Cardiovascular and Cerebrovascular Disease Higgins, Peter Dawson, Jesse Walters, Matthew Cardiovasc Psychiatry Neurol Review Article There is a now a wealth of epidemiological, animal, and clinical data to suggest the benefits of uric acid reduction and hxanthine oxidase inhibition in prevention of vascular disease. This review discusses the available epidemiological, preclinical, and clinical data and considers arguments for and against a role for serum uric acid in common cardiovascular disorders. It concludes that large scale trials with clinical endpoints are justified to address this important question and to define whether use of drugs such as allopurinol should be a routine part of preventative strategies. Hindawi Publishing Corporation 2009 2009-11-04 /pmc/articles/PMC2790135/ /pubmed/20029618 http://dx.doi.org/10.1155/2009/282059 Text en Copyright © 2009 Peter Higgins et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Higgins, Peter Dawson, Jesse Walters, Matthew The Potential for Xanthine Oxidase Inhibition in the Prevention and Treatment of Cardiovascular and Cerebrovascular Disease |
title | The Potential for Xanthine Oxidase Inhibition in the Prevention and Treatment of Cardiovascular and Cerebrovascular Disease |
title_full | The Potential for Xanthine Oxidase Inhibition in the Prevention and Treatment of Cardiovascular and Cerebrovascular Disease |
title_fullStr | The Potential for Xanthine Oxidase Inhibition in the Prevention and Treatment of Cardiovascular and Cerebrovascular Disease |
title_full_unstemmed | The Potential for Xanthine Oxidase Inhibition in the Prevention and Treatment of Cardiovascular and Cerebrovascular Disease |
title_short | The Potential for Xanthine Oxidase Inhibition in the Prevention and Treatment of Cardiovascular and Cerebrovascular Disease |
title_sort | potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790135/ https://www.ncbi.nlm.nih.gov/pubmed/20029618 http://dx.doi.org/10.1155/2009/282059 |
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