Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis

Thyroid dysfunction affects 1–4% of the population worldwide, causing defects including neurodevelopmental disorders, dwarfism and cardiac arrhythmia. Here, we show that KCNQ1 and KCNE2 form a TSH-stimulated, constitutively-active, thyrocyte K(+) channel required for normal thyroid hormone biosynthe...

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Detalles Bibliográficos
Autores principales: Roepke, Torsten K., King, Elizabeth C., Reyna-Neyra, Andrea, Paroder, Monika, Purtell, Kerry, Koba, Wade, Fine, Eugene, Lerner, Daniel J., Carrasco, Nancy, Abbott, Geoffrey W.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790327/
https://www.ncbi.nlm.nih.gov/pubmed/19767733
http://dx.doi.org/10.1038/nm.2029

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