Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

Macrophages exhibit endoplasmic reticulum (ER) stress when exposed to lipotoxic signals associated with atherosclerosis, although the pathophysiological significance and the underlying mechanisms remain unknown. Here, we demonstrate that mitigation of ER stress with a chemical chaperone results in m...

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Detalles Bibliográficos
Autores principales: Erbay, Ebru, Babaev, Vladimir R., Mayers, Jared R., Makowski, Liza, Charles, Khanichi N., Snitow, Melinda, Fazio, Sergio, Wiest, Michelle M., Watkins, Steven M., Linton, MacRae F., Hotamisligil, Gökhan S.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790330/
https://www.ncbi.nlm.nih.gov/pubmed/19966778
http://dx.doi.org/10.1038/nm.2067

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