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Derivation of an amino acid similarity matrix for peptide:MHC binding and its application as a Bayesian prior
BACKGROUND: Experts in peptide:MHC binding studies are often able to estimate the impact of a single residue substitution based on a heuristic understanding of amino acid similarity in an experimental context. Our aim is to quantify this measure of similarity to improve peptide:MHC binding predictio...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790471/ https://www.ncbi.nlm.nih.gov/pubmed/19948066 http://dx.doi.org/10.1186/1471-2105-10-394 |