Molecular Population Genetics of Human CYP3A Locus: Signatures of Positive Selection and Implications for Evolutionary Environmental Medicine

BACKGROUND: The human CYP3A gene cluster codes for cytochrome P450 (CYP) subfamily enzymes that catalyze the metabolism of various exogenous and endogenous chemicals and is an obvious candidate for evolutionary and environmental genomic study. Functional variants in the CYP3A locus may have undergon...

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Detalles Bibliográficos
Autores principales: Chen, Xiaoping, Wang, Haijian, Zhou, Gangqiao, Zhang, Xiumei, Dong, Xiaojia, Zhi, Lianteng, Jin, Li, He, Fuchu
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790508/
https://www.ncbi.nlm.nih.gov/pubmed/20019904
http://dx.doi.org/10.1289/ehp.0800528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790508/
https://www.ncbi.nlm.nih.gov/pubmed/20019904
http://dx.doi.org/10.1289/ehp.0800528

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