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Lead Exposure and Behavior among Young Children in Chennai, India
BACKGROUND: Lead exposure has long been associated with deficits in IQ among children. However, few studies have assessed the impact of lead on specific domains of behavior and cognition. OBJECTIVE: We evaluated the associations between lead and different domains of neurobehavior and their relative...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790517/ https://www.ncbi.nlm.nih.gov/pubmed/20019913 http://dx.doi.org/10.1289/ehp.0900625 |
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author | Roy, Ananya Bellinger, David Hu, Howard Schwartz, Joel Ettinger, Adrienne S. Wright, Robert O. Bouchard, Maryse Palaniappan, Kavitha Balakrishnan, Kalpana |
author_facet | Roy, Ananya Bellinger, David Hu, Howard Schwartz, Joel Ettinger, Adrienne S. Wright, Robert O. Bouchard, Maryse Palaniappan, Kavitha Balakrishnan, Kalpana |
author_sort | Roy, Ananya |
collection | PubMed |
description | BACKGROUND: Lead exposure has long been associated with deficits in IQ among children. However, few studies have assessed the impact of lead on specific domains of behavior and cognition. OBJECTIVE: We evaluated the associations between lead and different domains of neurobehavior and their relative sensitivity to lead. METHODS: We determined blood lead levels using a LeadCare instrument in 756 children 3–7 years of age attending pre- and elementary schools in Chennai, India. Anxiety, social problems, inattention, hyperactivity, and attention deficit hyperactivity disorder (ADHD), as well as executive function were assessed in children by their schoolteachers using Conners’ Teacher Rating Scales-39, Conners’ ADHD/Diagnostic and Statistical Manual for Mental Disorders, 4th Edition Scales (CADS), and the Behavior Rating Inventory of Executive Function questionnaires, with higher scores denoting worse behavior. Analyses were carried out using multivariate generalized estimating equations with comparisons of outcome Z-scores to assess the relative strengths of the associations between log-blood lead and the different domains of behavior. RESULTS: Mean blood lead level was 11.4 ± 5.3 μg/dL. Blood lead was associated with higher anxiety (β = 0.27, p = 0.01), social problems (β = 0.20, p = 0.02), and higher scores in the ADHD index (β = 0.17; p = 0.05). The effect estimate was highest for global executive function (β = 0.42; p< 0.001). CONCLUSIONS: Higher blood lead levels in this population of young children is associated with increased risk of neurobehavioral deficits and ADHD, with executive function and attention being particularly vulnerable domains to the effects of lead. |
format | Text |
id | pubmed-2790517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-27905172009-12-17 Lead Exposure and Behavior among Young Children in Chennai, India Roy, Ananya Bellinger, David Hu, Howard Schwartz, Joel Ettinger, Adrienne S. Wright, Robert O. Bouchard, Maryse Palaniappan, Kavitha Balakrishnan, Kalpana Environ Health Perspect Research BACKGROUND: Lead exposure has long been associated with deficits in IQ among children. However, few studies have assessed the impact of lead on specific domains of behavior and cognition. OBJECTIVE: We evaluated the associations between lead and different domains of neurobehavior and their relative sensitivity to lead. METHODS: We determined blood lead levels using a LeadCare instrument in 756 children 3–7 years of age attending pre- and elementary schools in Chennai, India. Anxiety, social problems, inattention, hyperactivity, and attention deficit hyperactivity disorder (ADHD), as well as executive function were assessed in children by their schoolteachers using Conners’ Teacher Rating Scales-39, Conners’ ADHD/Diagnostic and Statistical Manual for Mental Disorders, 4th Edition Scales (CADS), and the Behavior Rating Inventory of Executive Function questionnaires, with higher scores denoting worse behavior. Analyses were carried out using multivariate generalized estimating equations with comparisons of outcome Z-scores to assess the relative strengths of the associations between log-blood lead and the different domains of behavior. RESULTS: Mean blood lead level was 11.4 ± 5.3 μg/dL. Blood lead was associated with higher anxiety (β = 0.27, p = 0.01), social problems (β = 0.20, p = 0.02), and higher scores in the ADHD index (β = 0.17; p = 0.05). The effect estimate was highest for global executive function (β = 0.42; p< 0.001). CONCLUSIONS: Higher blood lead levels in this population of young children is associated with increased risk of neurobehavioral deficits and ADHD, with executive function and attention being particularly vulnerable domains to the effects of lead. National Institute of Environmental Health Sciences 2009-10 2009-06-26 /pmc/articles/PMC2790517/ /pubmed/20019913 http://dx.doi.org/10.1289/ehp.0900625 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Roy, Ananya Bellinger, David Hu, Howard Schwartz, Joel Ettinger, Adrienne S. Wright, Robert O. Bouchard, Maryse Palaniappan, Kavitha Balakrishnan, Kalpana Lead Exposure and Behavior among Young Children in Chennai, India |
title | Lead Exposure and Behavior among Young Children in Chennai, India |
title_full | Lead Exposure and Behavior among Young Children in Chennai, India |
title_fullStr | Lead Exposure and Behavior among Young Children in Chennai, India |
title_full_unstemmed | Lead Exposure and Behavior among Young Children in Chennai, India |
title_short | Lead Exposure and Behavior among Young Children in Chennai, India |
title_sort | lead exposure and behavior among young children in chennai, india |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790517/ https://www.ncbi.nlm.nih.gov/pubmed/20019913 http://dx.doi.org/10.1289/ehp.0900625 |
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