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Liver transplantation for acute-on-chronic liver failure

PURPOSE: To evaluate the outcome of liver transplantation for acute-on-chronic liver failure. PATIENTS AND METHODS: From November 1991 to December 2007, 517 patients underwent liver transplantation at Queen Mary Hospital, Hong Kong. Among them, 149 had acute-on-chronic liver failure as defined in th...

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Autores principales: Chan, Albert C., Fan, Sheung Tat, Lo, Chung Mau, Liu, Chi Leung, Chan, See Ching, Ng, Kelvin K., Yong, Boon Hun, Chiu, Alexander, Lam, Banny K.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790588/
https://www.ncbi.nlm.nih.gov/pubmed/19680733
http://dx.doi.org/10.1007/s12072-009-9148-8
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author Chan, Albert C.
Fan, Sheung Tat
Lo, Chung Mau
Liu, Chi Leung
Chan, See Ching
Ng, Kelvin K.
Yong, Boon Hun
Chiu, Alexander
Lam, Banny K.
author_facet Chan, Albert C.
Fan, Sheung Tat
Lo, Chung Mau
Liu, Chi Leung
Chan, See Ching
Ng, Kelvin K.
Yong, Boon Hun
Chiu, Alexander
Lam, Banny K.
author_sort Chan, Albert C.
collection PubMed
description PURPOSE: To evaluate the outcome of liver transplantation for acute-on-chronic liver failure. PATIENTS AND METHODS: From November 1991 to December 2007, 517 patients underwent liver transplantation at Queen Mary Hospital, Hong Kong. Among them, 149 had acute-on-chronic liver failure as defined in the recent Asian Pacific Association for the Study of Liver Consensus Meeting. Their clinical data were reviewed and their survival outcomes were compared with those of patients who underwent liver transplantation for fulminant hepatic failure and for cirrhosis only in the same period. RESULTS: The patients with acute-on-chronic liver failure included 50 patients having acute exacerbation of chronic hepatitis B and 99 cirrhotic patients with acute deterioration. Their median model for end-stage liver disease scores were 35 and 37, respectively. Preoperative infection (35%), hepatorenal syndrome (38%), and respiratory failure (28.8%) were common. One hundred and three patients received living donor liver grafts and 46 patients received deceased donor liver grafts. The hospital mortality rate was 4.7%. The 5-year survival rates were 93.2% for patients with acute exacerbation of chronic hepatitis B and 90.5% for cirrhotic patients with acute deterioration. The results were similar to those of the patients with fulminant hepatic failure (n = 37) and the patients having cirrhosis only (n = 301). CONCLUSIONS: Liver transplantation for acute-on-chronic liver failure is life-saving, and the survival rates it attains are similar to those attained by transplantation for other liver conditions.
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spelling pubmed-27905882010-01-05 Liver transplantation for acute-on-chronic liver failure Chan, Albert C. Fan, Sheung Tat Lo, Chung Mau Liu, Chi Leung Chan, See Ching Ng, Kelvin K. Yong, Boon Hun Chiu, Alexander Lam, Banny K. Hepatol Int Original Article PURPOSE: To evaluate the outcome of liver transplantation for acute-on-chronic liver failure. PATIENTS AND METHODS: From November 1991 to December 2007, 517 patients underwent liver transplantation at Queen Mary Hospital, Hong Kong. Among them, 149 had acute-on-chronic liver failure as defined in the recent Asian Pacific Association for the Study of Liver Consensus Meeting. Their clinical data were reviewed and their survival outcomes were compared with those of patients who underwent liver transplantation for fulminant hepatic failure and for cirrhosis only in the same period. RESULTS: The patients with acute-on-chronic liver failure included 50 patients having acute exacerbation of chronic hepatitis B and 99 cirrhotic patients with acute deterioration. Their median model for end-stage liver disease scores were 35 and 37, respectively. Preoperative infection (35%), hepatorenal syndrome (38%), and respiratory failure (28.8%) were common. One hundred and three patients received living donor liver grafts and 46 patients received deceased donor liver grafts. The hospital mortality rate was 4.7%. The 5-year survival rates were 93.2% for patients with acute exacerbation of chronic hepatitis B and 90.5% for cirrhotic patients with acute deterioration. The results were similar to those of the patients with fulminant hepatic failure (n = 37) and the patients having cirrhosis only (n = 301). CONCLUSIONS: Liver transplantation for acute-on-chronic liver failure is life-saving, and the survival rates it attains are similar to those attained by transplantation for other liver conditions. Springer-Verlag 2009-08-13 /pmc/articles/PMC2790588/ /pubmed/19680733 http://dx.doi.org/10.1007/s12072-009-9148-8 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Article
Chan, Albert C.
Fan, Sheung Tat
Lo, Chung Mau
Liu, Chi Leung
Chan, See Ching
Ng, Kelvin K.
Yong, Boon Hun
Chiu, Alexander
Lam, Banny K.
Liver transplantation for acute-on-chronic liver failure
title Liver transplantation for acute-on-chronic liver failure
title_full Liver transplantation for acute-on-chronic liver failure
title_fullStr Liver transplantation for acute-on-chronic liver failure
title_full_unstemmed Liver transplantation for acute-on-chronic liver failure
title_short Liver transplantation for acute-on-chronic liver failure
title_sort liver transplantation for acute-on-chronic liver failure
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790588/
https://www.ncbi.nlm.nih.gov/pubmed/19680733
http://dx.doi.org/10.1007/s12072-009-9148-8
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