Cargando…
Influence of local sequence context on damaged base conformation in human DNA polymerase ι: molecular dynamics studies of nucleotide incorporation opposite a benzo[a]pyrene-derived adenine lesion
Human DNA polymerase ι is a lesion bypass polymerase of the Y family, capable of incorporating nucleotides opposite a variety of lesions in both near error-free and error-prone bypass. With undamaged templating purines polymerase ι normally favors Hoogsteen base pairing. Polymerase ι can incorporate...
Autores principales: | Donny-Clark, Kerry, Broyde, Suse |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790882/ https://www.ncbi.nlm.nih.gov/pubmed/19767609 http://dx.doi.org/10.1093/nar/gkp745 |
Ejemplares similares
-
Mechanism of lesion verification by the human XPD helicase in nucleotide excision repair
por: Fu, Iwen, et al.
Publicado: (2022) -
Ubiquitin mediates the physical and functional interaction between human DNA polymerases η and ι
por: McIntyre, Justyna, et al.
Publicado: (2013) -
Enhanced spontaneous DNA twisting/bending fluctuations unveiled by fluorescence lifetime distributions promote mismatch recognition by the Rad4 nucleotide excision repair complex
por: Chakraborty, Sagnik, et al.
Publicado: (2018) -
Nucleotide excision repair of 2-acetylaminofluorene- and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies
por: Mu, Hong, et al.
Publicado: (2012) -
Structural, energetic and dynamic properties of guanine(C8)–thymine(N3) cross-links in DNA provide insights on susceptibility to nucleotide excision repair
por: Ding, Shuang, et al.
Publicado: (2012)