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Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria

The iron(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from Escherichia coli (EcAlkB) repairs alkylation damage in DNA by direct reversal. EcAlkB substrates include methylated bases, such as 1-methyladenine (m(1)A) and 3-methylcytosine (m(3)C), as well as certain bulkier lesions, for exam...

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Detalles Bibliográficos
Autores principales:	van den Born, Erwin, Bekkelund, Anders, Moen, Marivi N., Omelchenko, Marina V., Klungland, Arne, Falnes, Pål Ø.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790896/ https://www.ncbi.nlm.nih.gov/pubmed/19786499 http://dx.doi.org/10.1093/nar/gkp774

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