The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse

Killing by cytotoxic T lymphocytes (CTLs) is mediated by the secretion of lytic granules. The centrosome plays a key role in granule delivery, polarizing to the central supramolecular activation complex (cSMAC) within the immunological synapse upon T cell receptor (TCR) activation. Although stronger...

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Detalles Bibliográficos
Autores principales: Jenkins, Misty R., Tsun, Andy, Stinchcombe, Jane C., Griffiths, Gillian M.
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791175/
https://www.ncbi.nlm.nih.gov/pubmed/19833087
http://dx.doi.org/10.1016/j.immuni.2009.08.024

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