Vitamin B12-Impaired Metabolism Produces Apoptosis and Parkinson Phenotype in Rats Expressing the Transcobalamin-Oleosin Chimera in Substantia Nigra

BACKGROUND: Vitamin B12 is indispensable for proper brain functioning and cytosolic synthesis of S-adenosylmethionine. Whether its deficiency produces effects on viability and apoptosis of neurons remains unknown. There is a particular interest in investigating these effects in Parkinson disease whe...

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Detalles Bibliográficos
Autores principales: Orozco-Barrios, Carlos Enrique, Battaglia-Hsu, Shyue-Fang, Arango-Rodriguez, Martha Ligia, Ayala-Davila, Jose, Chery, Celine, Alberto, Jean-Marc, Schroeder, Henry, Daval, Jean-Luc, Martinez-Fong, Daniel, Gueant, Jean-Louis
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791211/
https://www.ncbi.nlm.nih.gov/pubmed/20027219
http://dx.doi.org/10.1371/journal.pone.0008268

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