Cargando…

An MHC-I Cytoplasmic Domain/HIV-1 Nef Fusion Protein Binds Directly to the μ Subunit of the AP-1 Endosomal Coat Complex

BACKGROUND: The down-regulation of the major histocompatibility complex class I (MHC-I) from the surface of infected cells by the Nef proteins of primate immunodeficiency viruses likely contributes to pathogenesis by providing evasion of cell-mediated immunity. HIV-1 Nef-induced down-regulation invo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, Rajendra Kumar, Lau, David, Noviello, Colleen M., Ghosh, Partho, Guatelli, John C.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791223/ https://www.ncbi.nlm.nih.gov/pubmed/20020046 http://dx.doi.org/10.1371/journal.pone.0008364

Ejemplares similares

HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail
por: Roeth, Jeremiah F., et al.
Publicado: (2004)

An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I
por: Dikeakos, Jimmy D., et al.
Publicado: (2012)

Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef
por: Jia, Xiaofei, et al.
Publicado: (2012)

AP-2 Adaptor Complex-Dependent Enhancement of HIV-1 Replication by Nef in the Absence of the Nef/AP-2 Targets SERINC5 and CD4
por: Olety, Balaji, et al.
Publicado: (2023)

Structural Basis of CD4 Downregulation by HIV-1 Nef
por: Kwon, Yonghwa, et al.
Publicado: (2020)

Contribution of the clathrin adaptor AP-1 subunit µ1 to acidic cluster protein sorting
por: Navarro Negredo, Paloma, et al.
Publicado: (2017)

Lovastatin Inhibits HIV-1-Induced MHC-I Downregulation by Targeting Nef–AP-1 Complex Formation: A New Strategy to Boost Immune Eradication of HIV-1 Infected Cells
por: Liu, Bingfeng, et al.
Publicado: (2019)

HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling
por: Dirk, Brennan S., et al.
Publicado: (2016)

How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4
por: Ren, Xuefeng, et al.
Publicado: (2014)

A Genome-Wide Screen for Machinery Involved in Downregulation of MHC Class I by HIV-1 Nef
por: Choma, Maja K., et al.
Publicado: (2015)

Nef-mediated Clathrin-coated Pit Formation
por: Foti, Michelangelo, et al.
Publicado: (1997)

Nef enhances HIV-1 replication and infectivity independently of SERINC5 in CEM T cells
por: Ramirez, Peter W., et al.
Publicado: (2023)

Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 γ–σ1 and AP-3 δ–σ3 hemicomplexes
por: Janvier, Katy, et al.
Publicado: (2003)

Phosphorylation of the AP2 μ subunit by AAK1 mediates high affinity binding to membrane protein sorting signals
por: Ricotta, Doris, et al.
Publicado: (2002)

A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation
por: Firrito, Claudia, et al.
Publicado: (2023)

Kinetic investigation reveals an HIV-1 Nef-dependent increase in AP-2 recruitment and productivity at endocytic sites
por: Iwamoto, Yuichiro, et al.
Publicado: (2023)

BMCC1 Is an AP-2 Associated Endosomal Protein in Prostate Cancer Cells
por: Harris, Janelle L., et al.
Publicado: (2013)

HIV-1 Nef: at the crossroads
por: Foster, John L, et al.
Publicado: (2008)

SIV Nef Proteins Recruit the AP-2 Complex to Antagonize Tetherin and Facilitate Virion Release
por: Zhang, Fengwen, et al.
Publicado: (2011)

The appendage domain of the AP-2 subunit is not required for assembly or invagination of clathrin-coated pits
Publicado: (1993)

AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis
por: Delevoye, Cédric, et al.
Publicado: (2009)

The activity of Nef on HIV-1 infectivity
por: Basmaciogullari, Stéphane, et al.
Publicado: (2014)

AP-1 subunits converge promiscuously at enhancers to potentiate transcription
por: Seo, Jungkyun, et al.
Publicado: (2021)

Inhibition of ER stress-mediated apoptosis in macrophages by nuclear-cytoplasmic relocalization of eEF1A by the HIV-1 Nef protein
por: Abbas, W, et al.
Publicado: (2012)

Inhibition of ER stress-mediated apoptosis in macrophages by nuclear-cytoplasmic relocalization of eEF1A by the HIV-1 Nef protein
por: Abbas, W, et al.
Publicado: (2012)

Small Molecule Inhibition of HIV-1–Induced MHC-I Down-Regulation Identifies a Temporally Regulated Switch in Nef Action
por: Dikeakos, Jimmy D., et al.
Publicado: (2010)

HPV-16 E7 Interacts with the Endocytic Machinery via the AP2 Adaptor μ2 Subunit
por: Basukala, Om, et al.
Publicado: (2022)

Sip1, a Conserved AP-1 Accessory Protein, Is Important for Golgi/Endosome Trafficking in Fission Yeast
por: Yu, Yang, et al.
Publicado: (2012)

A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities
por: Martínez-Bonet, Marta, et al.
Publicado: (2015)

Clathrin promotes incorporation of cargo into coated pits by activation of the AP2 adaptor μ2 kinase
por: Jackson, Antony P., et al.
Publicado: (2003)

AP-1 binding to sorting signals and release from clathrin-coated vesicles is regulated by phosphorylation
por: Ghosh, Pradipta, et al.
Publicado: (2003)

Study of the HIV-2 Env Cytoplasmic Tail Variability and Its Impact on Tat, Rev and Nef
por: Bakouche, Nordine, et al.
Publicado: (2013)

HEATR5B associates with dynein‐dynactin and promotes motility of AP1‐bound endosomal membranes
por: Madan, Vanesa, et al.
Publicado: (2023)

HIV-1 Nef Targets MHC-I and CD4 for Degradation Via a Final Common β-COP–Dependent Pathway in T Cells
por: Schaefer, Malinda R., et al.
Publicado: (2008)

HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity
por: Sami Saribas, A, et al.
Publicado: (2017)

The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation
por: Henrici, Ryan C., et al.
Publicado: (2020)

AP-1/σ1A and AP-1/σ1B adaptor-proteins differentially regulate neuronal early endosome maturation via the Rab5/Vps34-pathway
por: Candiello, Ermes, et al.
Publicado: (2016)

TNF and HIV-1 Nef: An Intimate Interplay
por: Herbein, Georges
Publicado: (2016)

Alphavirus RNA replicase is located on the cytoplasmic surface of endosomes and lysosomes
Publicado: (1988)

AP2S1 regulates APP degradation through late endosome–lysosome fusion in cells and APP/PS1 mice
por: Wen, Qi‐Xin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_54dk2hc16m22h4j3l430hl5tv3