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Analysis of the Association between CIMP and BRAF(V600E) in Colorectal Cancer by DNA Methylation Profiling

A CpG island methylator phenotype (CIMP) is displayed by a distinct subset of colorectal cancers with a high frequency of DNA hypermethylation in a specific group of CpG islands. Recent studies have shown that an activating mutation of BRAF (BRAF(V600E)) is tightly associated with CIMP, raising the...

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Detalles Bibliográficos
Autores principales:	Hinoue, Toshinori, Weisenberger, Daniel J., Pan, Fei, Campan, Mihaela, Kim, Myungjin, Young, Joanne, Whitehall, Vicki L., Leggett, Barbara A., Laird, Peter W.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791229/ https://www.ncbi.nlm.nih.gov/pubmed/20027224 http://dx.doi.org/10.1371/journal.pone.0008357

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