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YY1's DNA-Binding motifs in mammalian olfactory receptor genes
BACKGROUND: YY1 is an epigenetic regulator for a large number of mammalian genes. While performing genome-wide YY1 binding motif searches, we discovered that the olfactory receptor (OLFR) genes have an unusual cluster of YY1 binding sites within their coding regions. The statistical significance of...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791781/ https://www.ncbi.nlm.nih.gov/pubmed/19958529 http://dx.doi.org/10.1186/1471-2164-10-576 |
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author | Faulk, Christopher D Kim, Joomyeong |
author_facet | Faulk, Christopher D Kim, Joomyeong |
author_sort | Faulk, Christopher D |
collection | PubMed |
description | BACKGROUND: YY1 is an epigenetic regulator for a large number of mammalian genes. While performing genome-wide YY1 binding motif searches, we discovered that the olfactory receptor (OLFR) genes have an unusual cluster of YY1 binding sites within their coding regions. The statistical significance of this observation was further analyzed. RESULTS: About 45% of the olfactory genes in the mouse have a range of 4-8 YY1 binding sites within their respective 1 kb coding regions. Statistical analyses indicate that this enrichment of YY1 motifs has likely been driven by unknown selection pressures at the DNA level, but not serendipitously by some peptides enriched within the OLFR genes. Similar patterns are also detected in the OLFR genes of all mammals analyzed, but not in the OLFR genes of the fish lineage, suggesting a mammal-specific phenomenon. CONCLUSION: YY1, or YY1-related transcription factors, may help regulate olfactory receptor genes. Furthermore, the protein-coding regions of vertebrate genes can contain cis-regulatory elements for transcription factor binding as well as codons. |
format | Text |
id | pubmed-2791781 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27917812009-12-11 YY1's DNA-Binding motifs in mammalian olfactory receptor genes Faulk, Christopher D Kim, Joomyeong BMC Genomics Research article BACKGROUND: YY1 is an epigenetic regulator for a large number of mammalian genes. While performing genome-wide YY1 binding motif searches, we discovered that the olfactory receptor (OLFR) genes have an unusual cluster of YY1 binding sites within their coding regions. The statistical significance of this observation was further analyzed. RESULTS: About 45% of the olfactory genes in the mouse have a range of 4-8 YY1 binding sites within their respective 1 kb coding regions. Statistical analyses indicate that this enrichment of YY1 motifs has likely been driven by unknown selection pressures at the DNA level, but not serendipitously by some peptides enriched within the OLFR genes. Similar patterns are also detected in the OLFR genes of all mammals analyzed, but not in the OLFR genes of the fish lineage, suggesting a mammal-specific phenomenon. CONCLUSION: YY1, or YY1-related transcription factors, may help regulate olfactory receptor genes. Furthermore, the protein-coding regions of vertebrate genes can contain cis-regulatory elements for transcription factor binding as well as codons. BioMed Central 2009-12-03 /pmc/articles/PMC2791781/ /pubmed/19958529 http://dx.doi.org/10.1186/1471-2164-10-576 Text en Copyright ©2009 Faulk and Kim; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research article Faulk, Christopher D Kim, Joomyeong YY1's DNA-Binding motifs in mammalian olfactory receptor genes |
title | YY1's DNA-Binding motifs in mammalian olfactory receptor genes |
title_full | YY1's DNA-Binding motifs in mammalian olfactory receptor genes |
title_fullStr | YY1's DNA-Binding motifs in mammalian olfactory receptor genes |
title_full_unstemmed | YY1's DNA-Binding motifs in mammalian olfactory receptor genes |
title_short | YY1's DNA-Binding motifs in mammalian olfactory receptor genes |
title_sort | yy1's dna-binding motifs in mammalian olfactory receptor genes |
topic | Research article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791781/ https://www.ncbi.nlm.nih.gov/pubmed/19958529 http://dx.doi.org/10.1186/1471-2164-10-576 |
work_keys_str_mv | AT faulkchristopherd yy1sdnabindingmotifsinmammalianolfactoryreceptorgenes AT kimjoomyeong yy1sdnabindingmotifsinmammalianolfactoryreceptorgenes |