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Aminoglycoside resistance genes sgm and kgmB protect bacterial but not yeast small ribosomal subunits in vitro despite high conservation of the rRNA A-site
The aminoglycoside resistance genes sgm from Micromonospora zionensis and kgmB from Streptomyces tenebrarius were cloned into a yeast expression vector to test whether the encoded prokaryotic methylases can modify the 18S rRNA A-site and thus confer resistance to G-418. Despite the detectable presen...
Autores principales: | Tomic, Tatjana Ilic, Moric, Ivana, Conn, Graeme L., Vasiljevic, Branka |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791848/ https://www.ncbi.nlm.nih.gov/pubmed/18930134 http://dx.doi.org/10.1016/j.resmic.2008.09.006 |
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