PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling

BACKGROUND: Phosphatase of regenerating liver-3 (PRL-3) plays a causative role in tumor metastasis, but the underlying mechanisms are not well understood. In our previous study, we observed that PRL-3 could decrease tyrosine phosphorylation of integrin β1 and enhance activation of ERK1/2 in HEK293 c...

Descripción completa

Detalles Bibliográficos
Autores principales: Peng, Lirong, Xing, Xiaofang, Li, Weijun, Qu, Like, Meng, Lin, Lian, Shenyi, Jiang, Beihai, Wu, Jian, Shou, Chengchao
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792223/
https://www.ncbi.nlm.nih.gov/pubmed/19930715
http://dx.doi.org/10.1186/1476-4598-8-110

Ejemplares similares

Ejemplares similares