Cargando…

Effect of hydroxylpropyl-β-cyclodextrin on Solubility of Carvedilol

The present study was undertaken to examine the effect of pH and concentration of hydroxypropyl-β-cyclodextrin on the solubility of carvedilol as it shows pH-dependent solubility. The equilibrium solubility of carvedilol in a series of solutions of varying pH (from 1.2 to 11) was determined and comp...

Descripción completa

Detalles Bibliográficos
Autores principales: Shewale, B. D., Sapkal, N. P., Raut, N. A., Gaikwad, N. J., Fursule, R. A.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792477/
https://www.ncbi.nlm.nih.gov/pubmed/20046727
http://dx.doi.org/10.4103/0250-474X.41470
Descripción
Sumario:The present study was undertaken to examine the effect of pH and concentration of hydroxypropyl-β-cyclodextrin on the solubility of carvedilol as it shows pH-dependent solubility. The equilibrium solubility of carvedilol in a series of solutions of varying pH (from 1.2 to 11) was determined and compared with the equilibrium solubility of carvedilol in the presence of 20% hydroxypropyl-β-cyclodextrin at same pH values. It was observed that solubility of protonated form is more than neutral molecule. Hydroxypropyl-β-cyclodextrin resulted in increased solubility at all the pH. But inclusion in the cavity of hydroxypropyl-β-cyclodextrin might depend upon charge state of the molecule. So it can be concluded that solubility of carvedilol, can be increased either by the addition of hydroxypropyl-β-cyclodextrin or by adding pH lowering agents. But both these methods if are to be used together, pH should be selected carefully.