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Effect of hydroxylpropyl-β-cyclodextrin on Solubility of Carvedilol
The present study was undertaken to examine the effect of pH and concentration of hydroxypropyl-β-cyclodextrin on the solubility of carvedilol as it shows pH-dependent solubility. The equilibrium solubility of carvedilol in a series of solutions of varying pH (from 1.2 to 11) was determined and comp...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792477/ https://www.ncbi.nlm.nih.gov/pubmed/20046727 http://dx.doi.org/10.4103/0250-474X.41470 |
Sumario: | The present study was undertaken to examine the effect of pH and concentration of hydroxypropyl-β-cyclodextrin on the solubility of carvedilol as it shows pH-dependent solubility. The equilibrium solubility of carvedilol in a series of solutions of varying pH (from 1.2 to 11) was determined and compared with the equilibrium solubility of carvedilol in the presence of 20% hydroxypropyl-β-cyclodextrin at same pH values. It was observed that solubility of protonated form is more than neutral molecule. Hydroxypropyl-β-cyclodextrin resulted in increased solubility at all the pH. But inclusion in the cavity of hydroxypropyl-β-cyclodextrin might depend upon charge state of the molecule. So it can be concluded that solubility of carvedilol, can be increased either by the addition of hydroxypropyl-β-cyclodextrin or by adding pH lowering agents. But both these methods if are to be used together, pH should be selected carefully. |
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