Strategies for Enhanced Drug Delivery to the Central Nervous System

Treating central nervous system diseases is very challenging because of the presence of a variety of formidable obstacles that impede drug delivery. Physiological barriers like the blood-brain barrier and blood-cerebrospinal fluid barrier as well as various efflux transporter proteins make the entry...

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Detalles Bibliográficos
Autores principales: Dwibhashyam, V. S. N. M., Nagappa, A. N.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792490/
https://www.ncbi.nlm.nih.gov/pubmed/20046703
http://dx.doi.org/10.4103/0250-474X.41446
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author Dwibhashyam, V. S. N. M.
Nagappa, A. N.
author_facet Dwibhashyam, V. S. N. M.
Nagappa, A. N.
author_sort Dwibhashyam, V. S. N. M.
collection PubMed
description Treating central nervous system diseases is very challenging because of the presence of a variety of formidable obstacles that impede drug delivery. Physiological barriers like the blood-brain barrier and blood-cerebrospinal fluid barrier as well as various efflux transporter proteins make the entry of drugs into the central nervous system very difficult. The present review provides a brief account of the blood brain barrier, the P-glycoprotein efflux and various strategies for enhancing drug delivery to the central nervous system.
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spelling pubmed-27924902009-12-14 Strategies for Enhanced Drug Delivery to the Central Nervous System Dwibhashyam, V. S. N. M. Nagappa, A. N. Indian J Pharm Sci Review Article Treating central nervous system diseases is very challenging because of the presence of a variety of formidable obstacles that impede drug delivery. Physiological barriers like the blood-brain barrier and blood-cerebrospinal fluid barrier as well as various efflux transporter proteins make the entry of drugs into the central nervous system very difficult. The present review provides a brief account of the blood brain barrier, the P-glycoprotein efflux and various strategies for enhancing drug delivery to the central nervous system. Medknow Publications 2008 /pmc/articles/PMC2792490/ /pubmed/20046703 http://dx.doi.org/10.4103/0250-474X.41446 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Dwibhashyam, V. S. N. M.
Nagappa, A. N.
Strategies for Enhanced Drug Delivery to the Central Nervous System
title Strategies for Enhanced Drug Delivery to the Central Nervous System
title_full Strategies for Enhanced Drug Delivery to the Central Nervous System
title_fullStr Strategies for Enhanced Drug Delivery to the Central Nervous System
title_full_unstemmed Strategies for Enhanced Drug Delivery to the Central Nervous System
title_short Strategies for Enhanced Drug Delivery to the Central Nervous System
title_sort strategies for enhanced drug delivery to the central nervous system
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792490/
https://www.ncbi.nlm.nih.gov/pubmed/20046703
http://dx.doi.org/10.4103/0250-474X.41446
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