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Preparation and Evaluation of Buccoadhesive Films of Atenolol

This paper describes the preparation of new bilayered device comprising a drug containing mucoadhesive layer and a drug free backing layer. Bilaminated films were produced by a casting/ solvent evaporation technique. The mucoadhesive layer was composed of mixture of drug and sodium alginate with or...

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Detalles Bibliográficos
Autores principales: Satishbabu, B. K., Srinivasan, B. P.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792491/
https://www.ncbi.nlm.nih.gov/pubmed/20046708
http://dx.doi.org/10.4103/0250-474X.41451
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author Satishbabu, B. K.
Srinivasan, B. P.
author_facet Satishbabu, B. K.
Srinivasan, B. P.
author_sort Satishbabu, B. K.
collection PubMed
description This paper describes the preparation of new bilayered device comprising a drug containing mucoadhesive layer and a drug free backing layer. Bilaminated films were produced by a casting/ solvent evaporation technique. The mucoadhesive layer was composed of mixture of drug and sodium alginate with or without carbopol 934 P, and backing layer was made of ethyl cellulose. The double layer structure design was expected to provide drug delivery in a unidirectional fashion to the mucosa and avoid loss of drug due to wash out with saliva. The fabricated films were subjected to in vitro drug release, in vitro permeation through porcine buccal mucosa. The bilayered films were also evaluated for mucoadhesive strength, mucoadhesive time, folding endurance, hydration studies and tensile strength.
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spelling pubmed-27924912009-12-14 Preparation and Evaluation of Buccoadhesive Films of Atenolol Satishbabu, B. K. Srinivasan, B. P. Indian J Pharm Sci Research Paper This paper describes the preparation of new bilayered device comprising a drug containing mucoadhesive layer and a drug free backing layer. Bilaminated films were produced by a casting/ solvent evaporation technique. The mucoadhesive layer was composed of mixture of drug and sodium alginate with or without carbopol 934 P, and backing layer was made of ethyl cellulose. The double layer structure design was expected to provide drug delivery in a unidirectional fashion to the mucosa and avoid loss of drug due to wash out with saliva. The fabricated films were subjected to in vitro drug release, in vitro permeation through porcine buccal mucosa. The bilayered films were also evaluated for mucoadhesive strength, mucoadhesive time, folding endurance, hydration studies and tensile strength. Medknow Publications 2008 /pmc/articles/PMC2792491/ /pubmed/20046708 http://dx.doi.org/10.4103/0250-474X.41451 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Satishbabu, B. K.
Srinivasan, B. P.
Preparation and Evaluation of Buccoadhesive Films of Atenolol
title Preparation and Evaluation of Buccoadhesive Films of Atenolol
title_full Preparation and Evaluation of Buccoadhesive Films of Atenolol
title_fullStr Preparation and Evaluation of Buccoadhesive Films of Atenolol
title_full_unstemmed Preparation and Evaluation of Buccoadhesive Films of Atenolol
title_short Preparation and Evaluation of Buccoadhesive Films of Atenolol
title_sort preparation and evaluation of buccoadhesive films of atenolol
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792491/
https://www.ncbi.nlm.nih.gov/pubmed/20046708
http://dx.doi.org/10.4103/0250-474X.41451
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