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Formulation and in vitro Evaluation of Floating Capsules of Theophylline
Sustained release floating capsules for theophylline were fabricated using drug:polymer ratio of 30:70. The hydrocolloids were used in different proportions and four formulations were prepared. These formulations were optimized on the basis of buoyancy, matrix integrity, duration of floating and in...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792496/ https://www.ncbi.nlm.nih.gov/pubmed/20046717 http://dx.doi.org/10.4103/0250-474X.41460 |
Sumario: | Sustained release floating capsules for theophylline were fabricated using drug:polymer ratio of 30:70. The hydrocolloids were used in different proportions and four formulations were prepared. These formulations were optimized on the basis of buoyancy, matrix integrity, duration of floating and in vitro drug release. All the four formulations showed good buoyancy and matrix integrity. The duration of floating was more than 12 h for all formulations. In vitro drug release study of these formulations indicated controlled release of theophylline and about 76 percent drug was released at the end of 12 h. |
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