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Formulation and in vitro Evaluation of Floating Capsules of Theophylline

Sustained release floating capsules for theophylline were fabricated using drug:polymer ratio of 30:70. The hydrocolloids were used in different proportions and four formulations were prepared. These formulations were optimized on the basis of buoyancy, matrix integrity, duration of floating and in...

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Detalles Bibliográficos
Autores principales: Bhise, S. B., Aloorkar, N. H.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792496/
https://www.ncbi.nlm.nih.gov/pubmed/20046717
http://dx.doi.org/10.4103/0250-474X.41460
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author Bhise, S. B.
Aloorkar, N. H.
author_facet Bhise, S. B.
Aloorkar, N. H.
author_sort Bhise, S. B.
collection PubMed
description Sustained release floating capsules for theophylline were fabricated using drug:polymer ratio of 30:70. The hydrocolloids were used in different proportions and four formulations were prepared. These formulations were optimized on the basis of buoyancy, matrix integrity, duration of floating and in vitro drug release. All the four formulations showed good buoyancy and matrix integrity. The duration of floating was more than 12 h for all formulations. In vitro drug release study of these formulations indicated controlled release of theophylline and about 76 percent drug was released at the end of 12 h.
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spelling pubmed-27924962009-12-14 Formulation and in vitro Evaluation of Floating Capsules of Theophylline Bhise, S. B. Aloorkar, N. H. Indian J Pharm Sci Short Communications Sustained release floating capsules for theophylline were fabricated using drug:polymer ratio of 30:70. The hydrocolloids were used in different proportions and four formulations were prepared. These formulations were optimized on the basis of buoyancy, matrix integrity, duration of floating and in vitro drug release. All the four formulations showed good buoyancy and matrix integrity. The duration of floating was more than 12 h for all formulations. In vitro drug release study of these formulations indicated controlled release of theophylline and about 76 percent drug was released at the end of 12 h. Medknow Publications 2008 /pmc/articles/PMC2792496/ /pubmed/20046717 http://dx.doi.org/10.4103/0250-474X.41460 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Bhise, S. B.
Aloorkar, N. H.
Formulation and in vitro Evaluation of Floating Capsules of Theophylline
title Formulation and in vitro Evaluation of Floating Capsules of Theophylline
title_full Formulation and in vitro Evaluation of Floating Capsules of Theophylline
title_fullStr Formulation and in vitro Evaluation of Floating Capsules of Theophylline
title_full_unstemmed Formulation and in vitro Evaluation of Floating Capsules of Theophylline
title_short Formulation and in vitro Evaluation of Floating Capsules of Theophylline
title_sort formulation and in vitro evaluation of floating capsules of theophylline
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792496/
https://www.ncbi.nlm.nih.gov/pubmed/20046717
http://dx.doi.org/10.4103/0250-474X.41460
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