Cargando…

Comparative Molecular Field Analysis of Benzothiazepine Derivatives: Mitochondrial Sodium Calcium Exchange Inhibitors as Antidiabetic Agents

Mitochondrial sodium calcium exchange inhibitors are novel agents in the treatment of type-II diabetes due to their glucose dependent efficacy. While the compounds of this class are expected to correct hyperglycemia, they do not lower basal blood glucose level, thus avoiding the serious consequences...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dasoondi, A. S., Singh, V., Voleti, S. R., Tiwari, Meena
Formato:	Texto
Lenguaje:	English
Publicado:	Medknow Publications 2008
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792500/ https://www.ncbi.nlm.nih.gov/pubmed/20046710 http://dx.doi.org/10.4103/0250-474X.41453

Ejemplares similares

1,5-Benzothiazepine Derivatives: Green Synthesis, In Silico and In Vitro Evaluation as Anticancer Agents
por: Haroun, Michelyne, et al.
Publicado: (2022)

Sodium-calcium exchange /
Publicado: (1991)

Sodium-calcium exchange /
Publicado: (1989)

Reversal of Cisplatin Resistance by the 1,4‐Benzothiazepine Derivative, JTV‐519
por: Nakamura, Takashi, et al.
Publicado: (2001)

Molecular docking based screening of G6PS with 1, 5 Benzothiazepine derivates for a potential inhibitor
por: Chennu, Maruthi Malya Prasada Rao, et al.
Publicado: (2015)

Evaluation of 2,3-Dihydro-1,5-benzothiazepine Derivatives as Potential Tyrosinase Inhibitors: In Vitro and In Silico Studies
por: Al-Rooqi, Munirah M., et al.
Publicado: (2023)

The Neuroprotector Benzothiazepine CGP37157 Extends Lifespan in C. elegans Worms
por: García-Casas, Paloma, et al.
Publicado: (2019)

Role of Sodium/Calcium Exchangers in Tumors
por: Chovancova, Barbora, et al.
Publicado: (2020)

Sodium-glucose co-transporter 2 (SGLT2) inhibitors: a growing class of antidiabetic agents
por: Vivian, Eva M
Publicado: (2014)

Mitochondrial sodium/calcium exchanger NCLX regulates glycolysis in astrocytes, impacting on cognitive performance
por: Cabral-Costa, João Victor, et al.
Publicado: (2023)

SGLT inhibitors as antidiabetic agents: a comprehensive review
por: Kshirsagar, Rahul P., et al.
Publicado: (2020)

3,4-Dihydro-1,4-benzothiazepin-5(2H)-one
por: Chen, Zhi-Long, et al.
Publicado: (2007)

(Z)-3-Benzyl-1,5-benzothiazepin-4(5H)-one
por: Sabari, V., et al.
Publicado: (2012)

3-(4-Methoxybenzyl)-1,5-benzothiazepin-4(5H)-one
por: Selvakumar, R., et al.
Publicado: (2013)

Discovery Potent of Thiazolidinedione Derivatives as Antioxidant, α-Amylase Inhibitor, and Antidiabetic Agent
por: Sameeh, Manal Y., et al.
Publicado: (2021)

Mechanism of extracellular ion exchange and binding-site occlusion in the sodium-calcium exchanger
por: Liao, Jun, et al.
Publicado: (2016)

Allosteric Activation of Sodium–Calcium Exchange Activity by Calcium: Persistence at Low Calcium Concentrations
por: Reeves, John P., et al.
Publicado: (2003)

Sodium-calcium exchangers in rat trigeminal ganglion neurons
por: Kuroda, Hidetaka, et al.
Publicado: (2013)

Sodium-Calcium Exchange in Intracellular Calcium Handling of Human Airway Smooth Muscle
por: Sathish, Venkatachalem, et al.
Publicado: (2011)

Regulation of the sodium permeability of the luminal border of toad bladder by intracellular sodium and calcium: role of sodium-calcium exchange in the basolateral membrane
Publicado: (1981)

Stabilization of the Skeletal Muscle Ryanodine Receptor Ion Channel-FKBP12 Complex by the 1,4-Benzothiazepine Derivative S107
por: Mei, Yingwu, et al.
Publicado: (2013)

Sodium–glucose cotransporter 2 inhibitors: A drug with antidiabetic and cardioprotective properties
por: Li, Hung‐Yuan
Publicado: (2020)

Sodium-Glucose Cotransporter Inhibitors as Antidiabetic Drugs: Current Development and Future Perspectives
por: Maccari, Rosanna, et al.
Publicado: (2022)

Discovery and characterization of ORM‐11372, a novel inhibitor of the sodium‐calcium exchanger with positive inotropic activity
por: Otsomaa, Leena, et al.
Publicado: (2020)

Regulation of renal sodium calcium exchange by PTH: alteration with age.
por: Liang, C T, et al.
Publicado: (1990)

Nematode Sodium Calcium Exchangers: A Surprising Lack of Transport
por: Sharma, Vishal, et al.
Publicado: (2016)

Asymmetric Preorganization of Inverted Pair Residues in the Sodium-Calcium Exchanger
por: Giladi, Moshe, et al.
Publicado: (2016)

Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation
Publicado: (1992)

Sodium-calcium exchanger and multiple sodium channel isoforms in intra-epidermal nerve terminals
por: Persson, Anna-Karin, et al.
Publicado: (2010)

Synthesis of Novel 2,3-Dihydro-1,5-Benzothiazepines as α-Glucosidase Inhibitors: In Vitro, In Vivo, Kinetic, SAR, Molecular Docking, and QSAR Studies
por: Mehmood, Rabia, et al.
Publicado: (2022)

Cloning and Characterization of a Potassium-Dependent Sodium/Calcium Exchanger in Drosophila
por: Haug-Collet, K., et al.
Publicado: (1999)

Calmodulin Interacts with the Sodium/Calcium Exchanger NCX1 to Regulate Activity
por: Chou, Ai-Chuan, et al.
Publicado: (2015)

Heparin Oligosaccharides Have Antiarrhythmic Effect by Accelerating the Sodium-Calcium Exchanger
por: de Godoy, Carlos M. G., et al.
Publicado: (2018)

Effect of C reactive protein on the sodium-calcium exchanger 1 in cardiomyocytes
por: Xie, Yong, et al.
Publicado: (2021)

Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1
por: Xue, Jing, et al.
Publicado: (2023)

Two Birds One Stone: The Neuroprotective Effect of Antidiabetic Agents on Parkinson Disease—Focus on Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors
por: Lin, Kai-Jung, et al.
Publicado: (2021)

(Z)-3-(4-Chlorobenzyl)-1,5-benzothiazepin-4(5H)-one
por: Lakshmanan, D., et al.
Publicado: (2012)

(Z)-3-(2-Chlorobenzyl)-1,5-benzothiazepin-4(5H)-one
por: Sabari, V., et al.
Publicado: (2012)

Mechanochemical Synthesis of Thiazolidinone-Triazoles Derivatives as Antidiabetic Agents: Pharmacokinetics, Molecular Docking, and In Vitro Antidiabetic Properties
por: Taj, M. B., et al.
Publicado: (2023)

Insight into Structure Activity Relationship of DPP-4 Inhibitors for Development of Antidiabetic Agents
por: Mathur, Vishal, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_hqknhgurhe39m6pd76lftcvee6