High Performance Thin Layer Chromatographic Method for Simultaneous Estimation of Ibuprofen and Pseudoephedrine Hydrochloride

High performance thin layer chromatographic method is developed for simultaneous estimation of ibuprofen and pseudoephedrine hydrochloride in tablets. Silica gel 60F(254) plates were used as stationary phase and t.butanol: ethyl acetate: glacial acetic acid: water (7:4:2:2 v/v) as mobile phase. Wave...

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Detalles Bibliográficos
Autores principales: Chitlange, S. S., Sakarkar, D. M., Wankhede, S. B., Wadodkar, S. G.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792507/
https://www.ncbi.nlm.nih.gov/pubmed/20046759
http://dx.doi.org/10.4103/0250-474X.43018
Descripción
Sumario:High performance thin layer chromatographic method is developed for simultaneous estimation of ibuprofen and pseudoephedrine hydrochloride in tablets. Silica gel 60F(254) plates were used as stationary phase and t.butanol: ethyl acetate: glacial acetic acid: water (7:4:2:2 v/v) as mobile phase. Wavelength selected for analysis was 254 nm. Percent estimation of ibuprofen and pseudoephedrine hydrochloride was found to be 99.56% and 98.77%, respectively. Percent recovery for both the drugs was found in the range of 98.27% to 100.91%, respectively.

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