Quantitative Analysis of Propranolol Hydrochloride by High Performance Thin Layer Chromatography

A simple, accurate and precise HPTLC method has been developed for estimation of propranolol hydrochloride from bulk drug and tablet formulations. The separation was achieved on TLC plates using appropriate solvent system. The spots so developed were densitometrically scanned at 290 nm. The linearit...

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Detalles Bibliográficos
Autores principales: Bhavar, Girija, Chatpalliwar, V. A.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792509/
https://www.ncbi.nlm.nih.gov/pubmed/20046758
http://dx.doi.org/10.4103/0250-474X.43016
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author Bhavar, Girija
Chatpalliwar, V. A.
author_facet Bhavar, Girija
Chatpalliwar, V. A.
author_sort Bhavar, Girija
collection PubMed
description A simple, accurate and precise HPTLC method has been developed for estimation of propranolol hydrochloride from bulk drug and tablet formulations. The separation was achieved on TLC plates using appropriate solvent system. The spots so developed were densitometrically scanned at 290 nm. The linearity of the method was found to be within the concentration range of 200–2000 ng/spot. The validation parameters, tested in accordance with the requirements of ICH guidelines, prove the suitability of this method. The method was successively applied for determination of drug in tablets, wherein, no interference from tablet excipients was observed.
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spelling pubmed-27925092009-12-14 Quantitative Analysis of Propranolol Hydrochloride by High Performance Thin Layer Chromatography Bhavar, Girija Chatpalliwar, V. A. Indian J Pharm Sci Short Communications A simple, accurate and precise HPTLC method has been developed for estimation of propranolol hydrochloride from bulk drug and tablet formulations. The separation was achieved on TLC plates using appropriate solvent system. The spots so developed were densitometrically scanned at 290 nm. The linearity of the method was found to be within the concentration range of 200–2000 ng/spot. The validation parameters, tested in accordance with the requirements of ICH guidelines, prove the suitability of this method. The method was successively applied for determination of drug in tablets, wherein, no interference from tablet excipients was observed. Medknow Publications 2008 /pmc/articles/PMC2792509/ /pubmed/20046758 http://dx.doi.org/10.4103/0250-474X.43016 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Bhavar, Girija
Chatpalliwar, V. A.
Quantitative Analysis of Propranolol Hydrochloride by High Performance Thin Layer Chromatography
title Quantitative Analysis of Propranolol Hydrochloride by High Performance Thin Layer Chromatography
title_full Quantitative Analysis of Propranolol Hydrochloride by High Performance Thin Layer Chromatography
title_fullStr Quantitative Analysis of Propranolol Hydrochloride by High Performance Thin Layer Chromatography
title_full_unstemmed Quantitative Analysis of Propranolol Hydrochloride by High Performance Thin Layer Chromatography
title_short Quantitative Analysis of Propranolol Hydrochloride by High Performance Thin Layer Chromatography
title_sort quantitative analysis of propranolol hydrochloride by high performance thin layer chromatography
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792509/
https://www.ncbi.nlm.nih.gov/pubmed/20046758
http://dx.doi.org/10.4103/0250-474X.43016
work_keys_str_mv AT bhavargirija quantitativeanalysisofpropranololhydrochloridebyhighperformancethinlayerchromatography
AT chatpalliwarva quantitativeanalysisofpropranololhydrochloridebyhighperformancethinlayerchromatography

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