Cargando…

Chronomodulated Drug Delivery System of Salbutamol Sulphate for the Treatment of Nocturnal Asthma

A time dependent pulsed release system consisting of an effervescent core surrounded by consecutive layers of swelling and rupturable polymers was prepared and evaluated. The cores containing salbutamol sulphate as bioactive agent were prepared by direct compression method using different ratios of...

Descripción completa

Detalles Bibliográficos
Autores principales: Qureshi, J., Amir, Mohd., Ahuja, Alka, Baboota, Sanjula, Ali, J.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792514/
https://www.ncbi.nlm.nih.gov/pubmed/20046744
http://dx.doi.org/10.4103/0250-474X.43000
_version_ 1782175247033696256
author Qureshi, J.
Amir, Mohd.
Ahuja, Alka
Baboota, Sanjula
Ali, J.
author_facet Qureshi, J.
Amir, Mohd.
Ahuja, Alka
Baboota, Sanjula
Ali, J.
author_sort Qureshi, J.
collection PubMed
description A time dependent pulsed release system consisting of an effervescent core surrounded by consecutive layers of swelling and rupturable polymers was prepared and evaluated. The cores containing salbutamol sulphate as bioactive agent were prepared by direct compression method using different ratios of microcrystalline cellulose and effervescent agent and then coated sequentially with an inner swelling layer containing a hydrocolloid, hydroxypropylmethylcellulose E5 and an outer rupturable layer having Eudragit RL/RS (1:1). The effects of various processing and formulative parameters on the performance of system were studied. The rupture and dissolution tests were studied using the USP paddle method at 50 rpm in 0.1 N HCl and phosphate buffer pH 6.8. The lag time of the drug release decreased by increasing the inner swelling layer and increased by increasing the rupturing layer level. All the results obtained in the present study suggest that osmotic pumping effect was involved which eventually lead to the drug release.
format Text
id pubmed-2792514
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Medknow Publications
record_format MEDLINE/PubMed
spelling pubmed-27925142009-12-14 Chronomodulated Drug Delivery System of Salbutamol Sulphate for the Treatment of Nocturnal Asthma Qureshi, J. Amir, Mohd. Ahuja, Alka Baboota, Sanjula Ali, J. Indian J Pharm Sci Research Paper A time dependent pulsed release system consisting of an effervescent core surrounded by consecutive layers of swelling and rupturable polymers was prepared and evaluated. The cores containing salbutamol sulphate as bioactive agent were prepared by direct compression method using different ratios of microcrystalline cellulose and effervescent agent and then coated sequentially with an inner swelling layer containing a hydrocolloid, hydroxypropylmethylcellulose E5 and an outer rupturable layer having Eudragit RL/RS (1:1). The effects of various processing and formulative parameters on the performance of system were studied. The rupture and dissolution tests were studied using the USP paddle method at 50 rpm in 0.1 N HCl and phosphate buffer pH 6.8. The lag time of the drug release decreased by increasing the inner swelling layer and increased by increasing the rupturing layer level. All the results obtained in the present study suggest that osmotic pumping effect was involved which eventually lead to the drug release. Medknow Publications 2008 /pmc/articles/PMC2792514/ /pubmed/20046744 http://dx.doi.org/10.4103/0250-474X.43000 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Qureshi, J.
Amir, Mohd.
Ahuja, Alka
Baboota, Sanjula
Ali, J.
Chronomodulated Drug Delivery System of Salbutamol Sulphate for the Treatment of Nocturnal Asthma
title Chronomodulated Drug Delivery System of Salbutamol Sulphate for the Treatment of Nocturnal Asthma
title_full Chronomodulated Drug Delivery System of Salbutamol Sulphate for the Treatment of Nocturnal Asthma
title_fullStr Chronomodulated Drug Delivery System of Salbutamol Sulphate for the Treatment of Nocturnal Asthma
title_full_unstemmed Chronomodulated Drug Delivery System of Salbutamol Sulphate for the Treatment of Nocturnal Asthma
title_short Chronomodulated Drug Delivery System of Salbutamol Sulphate for the Treatment of Nocturnal Asthma
title_sort chronomodulated drug delivery system of salbutamol sulphate for the treatment of nocturnal asthma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792514/
https://www.ncbi.nlm.nih.gov/pubmed/20046744
http://dx.doi.org/10.4103/0250-474X.43000
work_keys_str_mv AT qureshij chronomodulateddrugdeliverysystemofsalbutamolsulphateforthetreatmentofnocturnalasthma
AT amirmohd chronomodulateddrugdeliverysystemofsalbutamolsulphateforthetreatmentofnocturnalasthma
AT ahujaalka chronomodulateddrugdeliverysystemofsalbutamolsulphateforthetreatmentofnocturnalasthma
AT babootasanjula chronomodulateddrugdeliverysystemofsalbutamolsulphateforthetreatmentofnocturnalasthma
AT alij chronomodulateddrugdeliverysystemofsalbutamolsulphateforthetreatmentofnocturnalasthma