Synthesis and Antiulcer Activity Studies of 2-(1′-Iminothioimido Substituted)-1′-Substituted Phenylbenzoic acids

Certain 2-(1'-iminothioimido substituted)-1'-substituted phenybenzoic acids (P(1-9)) were synthesized by reaction of phthalic anhydride with benzotriazole, 2-mercapto benzothiazole and 2-p-amino phenyl benzimidazole, respectively (A(1-3)) followed by imine formation with Schiff bases of th...

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Autores principales: Subudhi, B. B., Bhatta, D., Panda, P. K., Mishra, P., Pradhan, D.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792522/
https://www.ncbi.nlm.nih.gov/pubmed/20046753
http://dx.doi.org/10.4103/0250-474X.43009
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author Subudhi, B. B.
Bhatta, D.
Panda, P. K.
Mishra, P.
Pradhan, D.
author_facet Subudhi, B. B.
Bhatta, D.
Panda, P. K.
Mishra, P.
Pradhan, D.
author_sort Subudhi, B. B.
collection PubMed
description Certain 2-(1'-iminothioimido substituted)-1'-substituted phenybenzoic acids (P(1-9)) were synthesized by reaction of phthalic anhydride with benzotriazole, 2-mercapto benzothiazole and 2-p-amino phenyl benzimidazole, respectively (A(1-3)) followed by imine formation with Schiff bases of thiourea with salicylaldehyde, furfuraldehyde and 1-phenyl-3-methyl-5-pyrazolone. Antiulcer activity was evaluated using reduction in total acidity, free acidity and ulcer index as parameters. Compounds P(3), P(6), P(7) and P(9)(100 mg/kg) showed significant (P< 0.001) antiulcer action compared to control and omeprazole (40 mg/kg).
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spelling pubmed-27925222009-12-14 Synthesis and Antiulcer Activity Studies of 2-(1′-Iminothioimido Substituted)-1′-Substituted Phenylbenzoic acids Subudhi, B. B. Bhatta, D. Panda, P. K. Mishra, P. Pradhan, D. Indian J Pharm Sci Short Communications Certain 2-(1'-iminothioimido substituted)-1'-substituted phenybenzoic acids (P(1-9)) were synthesized by reaction of phthalic anhydride with benzotriazole, 2-mercapto benzothiazole and 2-p-amino phenyl benzimidazole, respectively (A(1-3)) followed by imine formation with Schiff bases of thiourea with salicylaldehyde, furfuraldehyde and 1-phenyl-3-methyl-5-pyrazolone. Antiulcer activity was evaluated using reduction in total acidity, free acidity and ulcer index as parameters. Compounds P(3), P(6), P(7) and P(9)(100 mg/kg) showed significant (P< 0.001) antiulcer action compared to control and omeprazole (40 mg/kg). Medknow Publications 2008 /pmc/articles/PMC2792522/ /pubmed/20046753 http://dx.doi.org/10.4103/0250-474X.43009 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Subudhi, B. B.
Bhatta, D.
Panda, P. K.
Mishra, P.
Pradhan, D.
Synthesis and Antiulcer Activity Studies of 2-(1′-Iminothioimido Substituted)-1′-Substituted Phenylbenzoic acids
title Synthesis and Antiulcer Activity Studies of 2-(1′-Iminothioimido Substituted)-1′-Substituted Phenylbenzoic acids
title_full Synthesis and Antiulcer Activity Studies of 2-(1′-Iminothioimido Substituted)-1′-Substituted Phenylbenzoic acids
title_fullStr Synthesis and Antiulcer Activity Studies of 2-(1′-Iminothioimido Substituted)-1′-Substituted Phenylbenzoic acids
title_full_unstemmed Synthesis and Antiulcer Activity Studies of 2-(1′-Iminothioimido Substituted)-1′-Substituted Phenylbenzoic acids
title_short Synthesis and Antiulcer Activity Studies of 2-(1′-Iminothioimido Substituted)-1′-Substituted Phenylbenzoic acids
title_sort synthesis and antiulcer activity studies of 2-(1′-iminothioimido substituted)-1′-substituted phenylbenzoic acids
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792522/
https://www.ncbi.nlm.nih.gov/pubmed/20046753
http://dx.doi.org/10.4103/0250-474X.43009
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