Determination of Ebastine in Pharmaceutical Formulations by HPLC

A simple, precise and rapid RP-HPLC method was developed for the determination of ebastine in pharmaceutical formulations. The method was carried out on a Phenomenex RP-C18 column using a mixture of methanol and water (90:10) and detection was done at 262 nm. The linearity range was 5-100 μg/ml. The...

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Detalles Bibliográficos
Autores principales: Prabu, S. L., Kumar, C. Dinesh, Shirwaikar, A., Shirwaikar, Annie
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792524/
https://www.ncbi.nlm.nih.gov/pubmed/20046762
http://dx.doi.org/10.4103/0250-474X.43022
Descripción
Sumario:A simple, precise and rapid RP-HPLC method was developed for the determination of ebastine in pharmaceutical formulations. The method was carried out on a Phenomenex RP-C18 column using a mixture of methanol and water (90:10) and detection was done at 262 nm. The linearity range was 5-100 μg/ml. The intra-day and inter-day precision were in the range of 0.22% to 0.49% and 0.24% to 0.73%, respectively.

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