Determination of Ebastine in Pharmaceutical Formulations by HPLC

A simple, precise and rapid RP-HPLC method was developed for the determination of ebastine in pharmaceutical formulations. The method was carried out on a Phenomenex RP-C18 column using a mixture of methanol and water (90:10) and detection was done at 262 nm. The linearity range was 5-100 μg/ml. The...

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Detalles Bibliográficos
Autores principales: Prabu, S. L., Kumar, C. Dinesh, Shirwaikar, A., Shirwaikar, Annie
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792524/
https://www.ncbi.nlm.nih.gov/pubmed/20046762
http://dx.doi.org/10.4103/0250-474X.43022
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author Prabu, S. L.
Kumar, C. Dinesh
Shirwaikar, A.
Shirwaikar, Annie
author_facet Prabu, S. L.
Kumar, C. Dinesh
Shirwaikar, A.
Shirwaikar, Annie
author_sort Prabu, S. L.
collection PubMed
description A simple, precise and rapid RP-HPLC method was developed for the determination of ebastine in pharmaceutical formulations. The method was carried out on a Phenomenex RP-C18 column using a mixture of methanol and water (90:10) and detection was done at 262 nm. The linearity range was 5-100 μg/ml. The intra-day and inter-day precision were in the range of 0.22% to 0.49% and 0.24% to 0.73%, respectively.
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spelling pubmed-27925242009-12-14 Determination of Ebastine in Pharmaceutical Formulations by HPLC Prabu, S. L. Kumar, C. Dinesh Shirwaikar, A. Shirwaikar, Annie Indian J Pharm Sci Short Communications A simple, precise and rapid RP-HPLC method was developed for the determination of ebastine in pharmaceutical formulations. The method was carried out on a Phenomenex RP-C18 column using a mixture of methanol and water (90:10) and detection was done at 262 nm. The linearity range was 5-100 μg/ml. The intra-day and inter-day precision were in the range of 0.22% to 0.49% and 0.24% to 0.73%, respectively. Medknow Publications 2008 /pmc/articles/PMC2792524/ /pubmed/20046762 http://dx.doi.org/10.4103/0250-474X.43022 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Prabu, S. L.
Kumar, C. Dinesh
Shirwaikar, A.
Shirwaikar, Annie
Determination of Ebastine in Pharmaceutical Formulations by HPLC
title Determination of Ebastine in Pharmaceutical Formulations by HPLC
title_full Determination of Ebastine in Pharmaceutical Formulations by HPLC
title_fullStr Determination of Ebastine in Pharmaceutical Formulations by HPLC
title_full_unstemmed Determination of Ebastine in Pharmaceutical Formulations by HPLC
title_short Determination of Ebastine in Pharmaceutical Formulations by HPLC
title_sort determination of ebastine in pharmaceutical formulations by hplc
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792524/
https://www.ncbi.nlm.nih.gov/pubmed/20046762
http://dx.doi.org/10.4103/0250-474X.43022
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