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Statistical Optimization of Sustained Release Venlafaxine HCI Wax Matrix Tablet
The purpose of this research was to prepare a sustained release drug delivery system of venlafaxine hydrochloride by using a wax matrix system. The effects of bees wax and carnauba wax on drug release profile was investigated. A 3(2) full factorial design was applied to systemically optimize the dru...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792543/ https://www.ncbi.nlm.nih.gov/pubmed/20046773 http://dx.doi.org/10.4103/0250-474X.44596 |
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author | Bhalekar, M. R. Madgulkar, A. R. Sheladiya, D. D. Kshirsagar, S. J. Wable, N. D. Desale, S. S. |
author_facet | Bhalekar, M. R. Madgulkar, A. R. Sheladiya, D. D. Kshirsagar, S. J. Wable, N. D. Desale, S. S. |
author_sort | Bhalekar, M. R. |
collection | PubMed |
description | The purpose of this research was to prepare a sustained release drug delivery system of venlafaxine hydrochloride by using a wax matrix system. The effects of bees wax and carnauba wax on drug release profile was investigated. A 3(2) full factorial design was applied to systemically optimize the drug release profile. Amounts of carnauba wax (X(1)) and bees wax (X(2)) were selected as independent variables and release after 12 h and time required for 50% (t(50)) drug release were selected as dependent variables. A mathematical model was generated for each response parameter. Both waxes retarded release after 12 h and increases the t(50) but bees wax showed significant influence. The drug release pattern for all the formulation combinations was found to be approaching Peppas kinetic model. Suitable combination of two waxes provided fairly good regulated release profile. The response surfaces and contour plots for each response parameter are presented for further interpretation of the results. The optimum formulations were chosen and their predicted results found to be in close agreement with experimental findings. |
format | Text |
id | pubmed-2792543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-27925432009-12-14 Statistical Optimization of Sustained Release Venlafaxine HCI Wax Matrix Tablet Bhalekar, M. R. Madgulkar, A. R. Sheladiya, D. D. Kshirsagar, S. J. Wable, N. D. Desale, S. S. Indian J Pharm Sci Research Paper The purpose of this research was to prepare a sustained release drug delivery system of venlafaxine hydrochloride by using a wax matrix system. The effects of bees wax and carnauba wax on drug release profile was investigated. A 3(2) full factorial design was applied to systemically optimize the drug release profile. Amounts of carnauba wax (X(1)) and bees wax (X(2)) were selected as independent variables and release after 12 h and time required for 50% (t(50)) drug release were selected as dependent variables. A mathematical model was generated for each response parameter. Both waxes retarded release after 12 h and increases the t(50) but bees wax showed significant influence. The drug release pattern for all the formulation combinations was found to be approaching Peppas kinetic model. Suitable combination of two waxes provided fairly good regulated release profile. The response surfaces and contour plots for each response parameter are presented for further interpretation of the results. The optimum formulations were chosen and their predicted results found to be in close agreement with experimental findings. Medknow Publications 2008 /pmc/articles/PMC2792543/ /pubmed/20046773 http://dx.doi.org/10.4103/0250-474X.44596 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Bhalekar, M. R. Madgulkar, A. R. Sheladiya, D. D. Kshirsagar, S. J. Wable, N. D. Desale, S. S. Statistical Optimization of Sustained Release Venlafaxine HCI Wax Matrix Tablet |
title | Statistical Optimization of Sustained Release Venlafaxine HCI Wax Matrix Tablet |
title_full | Statistical Optimization of Sustained Release Venlafaxine HCI Wax Matrix Tablet |
title_fullStr | Statistical Optimization of Sustained Release Venlafaxine HCI Wax Matrix Tablet |
title_full_unstemmed | Statistical Optimization of Sustained Release Venlafaxine HCI Wax Matrix Tablet |
title_short | Statistical Optimization of Sustained Release Venlafaxine HCI Wax Matrix Tablet |
title_sort | statistical optimization of sustained release venlafaxine hci wax matrix tablet |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792543/ https://www.ncbi.nlm.nih.gov/pubmed/20046773 http://dx.doi.org/10.4103/0250-474X.44596 |
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