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KRAS Mutations in Primary Colorectal Cancer Tumors and Related Metastases: A Potential Role in Prediction of Lung Metastasis

BACKGROUND: KRAS mutations in colorectal cancer primary tumors predict resistance to anti-Epidermal Growth Factor Receptor (EGFR) monoclonal antibody therapy in patients with metastatic colorectal cancer, and thus represent a true indicator of EGFR pathway activation status. METHODOLOGY/PRINCIPAL FI...

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Detalles Bibliográficos
Autores principales:	Cejas, Paloma, López-Gómez, Miriam, Aguayo, Cristina, Madero, Rosario, de Castro Carpeño, Javier, Belda-Iniesta, Cristóbal, Barriuso, Jorge, Moreno García, Víctor, Larrauri, Javier, López, Rocío, Casado, Enrique, Gonzalez-Barón, Manuel, Feliu, Jaime
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792724/ https://www.ncbi.nlm.nih.gov/pubmed/20020061 http://dx.doi.org/10.1371/journal.pone.0008199

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